ArticleACS omega2019
Highly Sensitive Endotoxin Assay Combining Peptide/Graphene Oxide and DNA-Modified Gold Nanoparticles.
Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Highly Sensitive Electrochemical Endotoxin Sensor Based on Redox Cycling Using an Interdigitated Array Electrode Device.Micromachines · 2023Article
- The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics.Biosensors · 2021Review
- Graphene biosensors for bacterial and viral pathogens.Biosensors & bioelectronics · 2020Review
- Ultrasensitive Electrochemical DNA Biosensor Fabrication by Coupling an Integral Multifunctional Zirconia-Reduced Graphene Oxide-Thionine Nanocomposite and Exonuclease I-Assisted Cleavage.Frontiers in chemistry · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endotoxin is a highly toxic stimulator originated from the outer membrane of Gram-negative bacteria, which should be monitored sensitively and selectively for human health concerns. Traditional detection methods mainly rely on limulus amoebocyte lysate assay. However, it suffers drawbacks like the narrow detection range, and the results may be environment-dependent. In this work, we have developed a sensitive electrochemical biosensor for endotoxin assay. Peptide is first designed as specific recognition element toward endotoxin. Graphene oxide and DNA-modified gold nanoparticles are then used to enhance the electrochemical signal. The analytical performances are excellent with the limit of detection as low as 0.001 EU mL
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Registered trials
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