Evidence map›Paper›PMID 31508507›Full record

ArticleCommunications biology2019

Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA.

Akram A Da'dara, Andrea Angeli, Marta Ferraroni, Claudiu T Supuran, Patrick J Skelly

Abstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Comprehensive Mapping of Immune Nanobody Repertoires with NanoMAP.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Development of Praziquantel sulphonamide derivatives as antischistosomal drugs.Journal of enzyme inhibition and medicinal chemistry · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Coumarin carbonic anhydrase inhibitors from natural sources.Journal of enzyme inhibition and medicinal chemistry · 2020
    Review
  15. Article
  16. Article
  17. Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase fromInternational journal of molecular sciences · 2020
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Akram A Da'dara1Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA USA.
Andrea Angeli2Sezione di Scienze Farmaceutiche e Nutraceutiche, Dipartimento Neurofarba, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence Italy.
Marta Ferraroni3Dipartimento di Chimica " Ugo Schiff", Università di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence Italy.
Claudiu T Supuran2Sezione di Scienze Farmaceutiche e Nutraceutiche, Dipartimento Neurofarba, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence Italy.
Patrick J Skelly1Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA USA.ORCID 0000-0002-5733-0524

Funding

Gene silencing in schistosomes using RNAiR01AI056273 · NIAID · TUFTS UNIVERSITY BOSTON · PI Patrick J Skelly · 2004 to 2026
$7.2M
Inhibiting tegumental carbonic anhydrase as a novel treatment for schistosomiasisR21AI111011 · NIAID · TUFTS UNIVERSITY BOSTON · PI SKELLY, PATRICK J · 2014 to 2015
$436k
Functional Characterization of the Schistosome TegumentR56AI056273 · NIAID · TUFTS UNIVERSITY BOSTON · PI SKELLY, PATRICK J · 2021 to 2021
$413k
NIAID NIH HHS HHSN272201000009INIAID NIH HHS R01 AI056273NIAID NIH HHS R21 AI111011NIAID NIH HHS R56 AI056273
6 · The paper itself

Abstract

The intravascular parasitic worm

Indexed as

Models, MolecularAnimalsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesCloning, MolecularFemaleHost-Parasite InteractionsHumansMaleMolecular ConformationMolecular StructureRecombinant Fusion ProteinsSchistosomaVirulenceCarbonic Anhydrase InhibitorsCarbonic AnhydrasesRecombinant Fusion ProteinsHydrolasesParasite biologyParasite developmentParasite physiologyVascular diseases

Identifiers

PMID31508507
PMCPMC6728359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.