ArticleNPJ breast cancer2019
Success rates of re-excision after positive margins for invasive lobular carcinoma of the breast.
Article in NPJ breast cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07131735 (Intraoperative Detection of Breast Cancer by Electrosurgical Gas Analysis and Artificial Intelligence), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intraoperative Detection of Breast Cancer by Electrosurgical Gas Analysis and Artificial Intelligence
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reducing re-excision rates in breast conserving surgery with Margin Probe: systematic review.The British journal of surgery · 2024Pooled it
- The SLIM technique: introducing a novel way for the orientation of cavity shaves during breast conserving surgery in breast cancer patients.Gland surgery · 2026Article
- Oncoplastic Breast Surgery: Optimizing Resection Margins in Addition to Aesthetic Outcomes.Aesthetic plastic surgery · 2026Article
- Molecular and Biological Features of Invasive Lobular Carcinoma: Toward New Treatment Strategies.Annals of surgical oncology · 2026Review
- Radiation therapy for lobular breast cancer: opportunities and challenges for leveraging radiosensitivity.NPJ breast cancer · 2025Review
- Balancing risks of surgical complications and positive margins for patients with invasive lobular carcinoma of the breast and elevated BMI: An institutional cohort study.American journal of surgery · 2025Article
- Psychological Considerations Associated with Lobular Breast Cancer.Current psychiatry reports · 2025Review
- Variation in surgical treatment by body mass index in patients with invasive lobular carcinoma of the breast.Breast cancer research and treatment · 2024Article
- Successful Breast Conservation After Neoadjuvant Chemotherapy in Lobular Breast Cancer: The Role of Menopausal Status in Response to Treatment.Annals of surgical oncology · 2023Article
- Cost minimization in breast conserving surgery: a comparative study of radiofrequency spectroscopy and full cavity shave margins.Cost effectiveness and resource allocation : C/E · 2023Article
- Immediate or delayed oncoplastic surgery after breast conserving surgery at the Netherlands Cancer Institute: a cohort study of 251 cases.Breast cancer research and treatment · 2023Article
- Invasive Lobular Carcinoma: A Review of Imaging Modalities with Special Focus on Pathology Concordance.Healthcare (Basel, Switzerland) · 2023Review
- Compression optical coherence elastography versus strain ultrasound elastography for breast cancer detection and differentiation: pilot study.Biomedical optics express · 2022Article
- The Importance of the Pathological Perspective in the Management of the Invasive Lobular Carcinoma.The breast journal · 2022Article
- Radiological Underestimation of Tumor Size Influences the Success Rate of Re-Excision after Breast-conserving Surgery.European journal of breast health · 2021Article
- Survival Outcomes in Invasive Lobular Carcinoma Compared to Oestrogen Receptor-Positive Invasive Ductal Carcinoma.Cancers · 2021Article
- Comprehensive Review of Molecular Mechanisms and Clinical Features of Invasive Lobular Cancer.The oncologist · 2021Review
- Handheld macroscopic Raman spectroscopy imaging instrument for machine-learning-based molecular tissue margins characterization.Journal of biomedical optics · 2021Article
- Estrogen Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular Carcinoma Cell Lines Requires WNT4.Cancers · 2020Article
- Lobular Breast Cancer: A Review.Frontiers in oncology · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rates of positive margins after surgical resection of invasive lobular carcinoma (ILC) are high (ranging from 18 to 60%), yet the efficacy of re-excision lumpReceptor subtypeectomy for clearing positive margins is unknown. Concerns about the diffuse nature of ILC may drive increased rates of completion mastectomy to treat positive margins, thus lowering breast conservation rates. We therefore determined the success rate of re-excision lumpectomy in women with ILC and positive margins after surgical resection. We identified 314 cases of stage I-III ILC treated with breast conserving surgery (BCS) at the University of California, San Francisco. Surgical procedures, pathology reports, and outcomes were analyzed using univariate and multivariate statistics and Cox-proportional hazards models. We evaluated outcomes before and after the year 2014, when new margin management consensus guidelines were published. Positive initial margins occurred in 118 (37.6%) cases. Of these, 62 (52.5%) underwent re-excision lumpectomy, which cleared the margin in 74.2%. On multivariate analysis, node negativity was significantly associated with successful re-excision (odds ratio [OR] 3.99, 95% CI 1.15-13.81,
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