ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019
Fine-Tunable and Injectable 3D Hydrogel for On-Demand Stem Cell Niche.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- LCST/UCST behavior of polysaccharides for hydrogel fabrication.RSC advances · 2024Review
- Modulus-dependent effects on neurogenic, myogenic, and chondrogenic differentiation of human mesenchymal stem cells in three-dimensional hydrogel cultures.Journal of biomedical materials research. Part A · 2023Article
- Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis.Bioactive materials · 2022Article
- Human Umbilical Cord Mesenchymal Stem Cells Encapsulated with Pluronic F-127 Enhance the Regeneration and Angiogenesis of Thin Endometrium in Rat via Local IL-1Stem cells international · 2022Article
- Injectable silk nanofiber hydrogels as stem cell carriers to accelerate wound healing.Journal of materials chemistry. B · 2021Article
- Reversible Speed Regulation of Self-Propelled Janus Micromotors via Thermoresponsive Bottle-Brush Polymers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Mechanobiological Strategies to Enhance Stem Cell Functionality for Regenerative Medicine and Tissue Engineering.Frontiers in cell and developmental biology · 2021Review
- Article
- Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells.RSC advances · 2020Article
- Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications.Molecules (Basel, Switzerland) · 2020Review
- Creating Physicochemical Gradients in Modular Microporous Annealed Particle Hydrogels via a Microfluidic Method.Advanced functional materials · 2020Article
- Advances in the Application of Supramolecular Hydrogels for Stem Cell Delivery and Cartilage Tissue Engineering.Frontiers in bioengineering and biotechnology · 2020Review
- Article
- Fine-Tunable and Injectable 3D Hydrogel for On-Demand Stem Cell Niche.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Restoration of olfactory dysfunctions by nanomaterials and stem cells-based therapies: Current status and future perspectives.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem-cell-based tissue engineering requires increased stem cell retention, viability, and control of differentiation. The use of biocompatible scaffolds encapsulating stem cells typically addresses the first two problems. To achieve control of stem cell fate, fine-tuned biocompatible scaffolds with bioactive molecules are necessary. However, given that the fine-tuning of stem cell scaffolds is associated with UV irradiation and in situ scaffold gelation, this process is in conflict with injectability. Herein, a fine-tunable and injectable 3D hydrogel system is developed with the use of thermosensitive poly(organophosphazene) bearing β-cyclodextrin (β-CD PPZ) and two types of adamantane-peptides (Ad-peptides) that are associated with mesenchymal stem cell (MSC) differentiation and that serve as stoichiometrically controlled pendants for fine-tuning. Given that complexation of hosts and guests subject to strict stoichiometric control is achieved with simple mixing, these fabricated hydrogels exhibit well-aligned, fine-tuning responses, even in living animals. Injection of MSCs in fine-tuned hydrogels also results in various chondrogenic differentiation levels at three weeks postinjection. This is attributed to the differential controls of Ad-peptides, if MSC preconditioning is excluded. Eventually, the fine-tunable and injectable 3D hydrogel could be applied as platform technology by simply switching the types of peptides bearing adamantane and their stoichiometry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.