Evidence map›Paper›PMID 31508244›Full record

ArticleInternational journal of retina and vitreous2019

Microperimetry and OCT angiography evaluation of patients with ischemic diabetic macular edema treated with monthly intravitreal bevacizumab: a pilot study.

Felipe Pereira, Bruno Rebello Godoy, Mauricio Maia, Caio Vinicius Regatieri

Open access · goldAbstract read
In one paragraph

Article in International journal of retina and vitreous, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Clinical and optical coherence tomography angiography-based risk factors for reduced retinal sensitivity in diabetic macular edema.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023
    Review
  8. Review
  9. Article
  10. Diabetic macular ischaemia- a new therapeutic target?Progress in retinal and eye research · 2022
    Review
  11. Article
  12. Indicators of Visual Prognosis in Diabetic Macular Oedema.Journal of personalized medicine · 2021
    Review
  13. Article
  14. Looking Ahead: Visual and Anatomical Endpoints in Future Trials of Diabetic Macular Ischemia.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2021
    Review
  15. Paracentral acute middle maculopathy-review of the literature.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Felipe Pereira1Departamento de Oftalmologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu 821, São Paulo, SP 04023-062 Brazil.
Bruno Rebello Godoy1Departamento de Oftalmologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu 821, São Paulo, SP 04023-062 Brazil.
Mauricio Maia1Departamento de Oftalmologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu 821, São Paulo, SP 04023-062 Brazil.
Caio Vinicius Regatieri1Departamento de Oftalmologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu 821, São Paulo, SP 04023-062 Brazil.
Universidade Federal de São Paulo · BRTufts Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFunctional and anatomical evaluation of patients with ischemic diabetic macular edema after monthly injections of Bevacizumab.

methodsFive eyes from five patients with diabetic macular edema associated with macular ischemia in fluorescein angiography (FA), received 6 monthly intravitreal injections of Bevacizumab. All subjects underwent SD-OCT, FA, OCT angiography (OCTA) and microperimetry at baseline and after 6 months follow-up. Primary outcome measures were improvement of best corrected visual acuity (BCVA), microperimetry and assessment of macular perfusion (foveal avascular zone size and capillary loss).

resultsFive patients completed the follow-up. BCVA improved from 20/180 to 20/74 (

conclusionsMonthly intravitreal Bevacizumab in patients with ischemic diabetic macular edema improved BCVA and macular sensitivity without compromise of perfusion in the macula. Capillary dropout areas in OCTA correlated with lower retinal sensitivity on microperimetry.

Indexed as

Anti-VEGFDiabetic macular edemaDiabetic macular ischemiaPharmacotherapy

Identifiers

PMID31508244
PMCPMC6721188
OpenAlexW2971703825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.