Evidence map›Paper›PMID 31508187›Full record

ArticleActa endocrinologica (Bucharest, Romania : 2005)

THE MULTIFARIOUS CUSHING'S - LESSONS FROM A CASE SERIES.

I Ilie, V Ciubotaru, A Tulin, D Hortopan, A Caragheorgheopol, M Purice, C Neamtu, V I Elian, A Banica, L Oprea and 1 more

Abstract readCase Reports
In one paragraph

Article in Acta endocrinologica (Bucharest, Romania : 2005). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Hidden hypercortisolism: a too frequently neglected clinical condition.Journal of endocrinological investigation · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

I Ilie"C.I.Parhon" National Institute of Endocrinology, Bucharest, Romania.
V Ciubotaru"Bagdasar Arseni" Hospital - Neurosurgery, "Carol Davila" University of Medicine and Pharmacy - Bucharest, Romania.
A TulinAnatomy - Bucharest, Romania.
D Hortopan"C.I.Parhon" National Institute of Endocrinology, Bucharest, Romania.
A Caragheorgheopol"C.I.Parhon" National Institute of Endocrinology, Bucharest, Romania.
M Purice"C.I.Parhon" National Institute of Endocrinology, Bucharest, Romania.
C NeamtuSanador Clinical Hospital, Bucharest, Romania.
V I ElianDiabetes, Nutrition and Metabolic Diseases - Bucharest, Romania.
A Banica"C.I.Parhon" National Institute of Endocrinology, Bucharest, Romania.
L Oprea"C.I.Parhon" National Institute of Endocrinology, Bucharest, Romania.
M Musat"C.I.Parhon" National Institute of Endocrinology, Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endogenous Cushing's syndrome is rare, with an incidence of 0.7-2.4 per a million people a year. Clinical presentation of Cushing syndrome can be pleomorphic, and establishing diagnosis can be difficult. Early recognition and rapid control of hypercortisolaemia are necessary to decrease morbidity and mortality in these patients. We report a series of 6 endogenous Cushing's syndromes of different etiologies (4 Cushing's disease and 2 adrenal Cushing's syndrome) assessed in our endocrine department over a decade (2009-2019). In order to highlight the diversity of clinical forms, diagnostic tools and specific management of this condition we labelled each case suggestively: the typical Cushing's disease, the Pseudo Cushing's, the elusive Cushing's disease, the mild autonomous cortisol hypersecretion, Cushing's syndrome in pregnancy and Cushing's disease with thromboembolism. We discussed their particularities which were revelatory for the diagnosis, such as dermatologic, cardiovascular, musculoskeletal, neuropsychiatric, or reproductive signs, reviewing literature for each manifestation. We also discuss the commonalities and differences in laboratory and imagistic findings. Therapeutic approach can also differ with respect to the particular condition of each patient and the multiple choices of therapy will be reviewed.

Indexed as

Cushing’s disease.Cushing’s syndrome

Identifiers

PMID31508187
PMCPMC6711653

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.