ArticleActa endocrinologica (Bucharest, Romania : 2005)
OSTEOPOROSIS AND FRACTURE RISK IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.
Article in Acta endocrinologica (Bucharest, Romania : 2005). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- The hidden influence of type 2 diabetes on bone mineral density across the lifespan: a Mendelian randomization study.Hormones (Athens, Greece) · 2025Article
- Correlation between thyroid sensitivity indices and bone metabolism in newly diagnosed middle aged and elderly patients with type 2 diabetes mellitus with normal thyroid function.BMC endocrine disorders · 2025Article
- HMGB1 and TLR4 as biomarkers for osteoporosis risk in type 2 diabetes mellitus: a cross-sectional study.BMC endocrine disorders · 2025Article
- A Sex Comparison of Fall and Fracture Occurrence in the Elderly Diabetic Population: A Quantitative Study.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Osteoporosis as the Female-Specific Risk Factor for Dynapenia in Elderly Patients with Type 2 Diabetes.Journal of clinical medicine · 2024Article
- Article
- Effects of antidiabetic drugs on bone metabolism.Advances in laboratory medicine · 2024Article
- Comparison of Trabecular Bone Score-Adjusted Fracture Risk Assessment (TBS-FRAX) and FRAX Tools for Identification of High Fracture Risk among Taiwanese Adults Aged 50 to 90 Years with or without Prediabetes and Diabetes.Medicina (Kaunas, Lithuania) · 2022Article
- Cognitive perspective of osteoporosis among adults with type 2 diabetes mellitus: The Malaysian case.Endocrinology, diabetes & metabolism · 2022Observational
- Bone mass and microarchitecture in T2DM patients and corticosteroids therapy: the Bushehr Elderly Health program.Journal of diabetes and metabolic disorders · 2022Article
- Distributions of Microdamage Are Altered Between Trabecular Rods and Plates in Cancellous Bone From Men With Type 2 Diabetes Mellitus.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- The role of advanced glycation end products in fracture risk assessment in postmenopausal type 2 diabetic patients.Frontiers in endocrinology · 2022Article
- Prevalent Morphometrically Assessed Vertebral Fractures in Individuals With Type 2 Diabetes, Prediabetes and Normal Glucose Metabolism: The Maastricht Study.Frontiers in endocrinology · 2022Article
- Safety profile of sodium glucose co-transporter 2 (SGLT2) inhibitors: A brief summary.Frontiers in cardiovascular medicine · 2022Review
- Fracture Patterns in Type 1 and Type 2 Diabetes Mellitus: A Narrative Review of Recent Literature.Current osteoporosis reports · 2021Review
- Review
- Review
- Bone metabolic biomarker-based diagnosis of type 2 diabetes osteoporosis by support vector machine.Annals of translational medicine · 2021Article
- JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of fragility fractures compared to the general population. The pathogenesis of the elevated fracture risk is multifactorial and still largely elusive. In contrast to primary osteoporosis, in T2DM the bone mineral density (BMD) is increased compared to controls, suggesting that specific alterations in bone quality occur in diabetic patients. Even more, the specific increase in BMD observed in these patients impairs at least in part both the classical diagnosis of osteoporosis by dual-energy X-ray absorptiometry (DXA) and the current fracture risk estimation by FRAX (fracture risk assessment tool). Trabecular bone score (TBS) and TBS-adjusted FRAX could improve fracture risk estimation in patients with T2DM but improved tools are needed in the future as well as specific risk stratification criteria. Decreases in the fracture risk of patients with T2DM can be obtained by optimal diabetes control and standard treatment of osteoporosis (most drugs appear to have similar efficacy in patients with T2DM and primary osteoporosis).
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