Evidence map›Paper›PMID 31507588›Full record

SynthesisFrontiers in immunology2019

Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans.

Hanna IJspeert, Pauline A van Schouwenburg, Ingrid Pico-Knijnenburg, Jan Loeffen, Laurence Brugieres, Gertjan J Driessen, Claudia Blattmann, Manon Suerink, Danuta Januszkiewicz-Lewandowska, Amedeo A Azizi and 3 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Tandem Substitutions in Somatic Hypermutation.Frontiers in immunology · 2021
    Article
  3. Position-Dependent Differential Targeting of Somatic Hypermutation.Journal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 5 countries.

Hanna IJspeertDepartment of Immunology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, Netherlands.
Pauline A van SchouwenburgDepartment of Immunology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, Netherlands.
Ingrid Pico-KnijnenburgLaboratory for Immunology, Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
Jan LoeffenDepartment of Pediatric Oncology and Hematology, Erasmus Medical Centre, Sophia Children's Hospital, Rotterdam, Netherlands.
Laurence BrugieresDepartment of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Campus, Villejuif, France.
Gertjan J DriessenDepartment of Paediatrics, Juliana Children's Hospital, Haga Teaching Hospital, The Hague, Netherlands.
Claudia BlattmannDepartment of Pediatric Hematology and Oncology, Palliative Care, Olgahospital Klinikum Stuttgart, Stuttgart, Germany.
Manon SuerinkDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands.
Danuta Januszkiewicz-LewandowskaDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznań, Poland.
Amedeo A AziziDepartment of Pediatrics and Adolescent Medicine, Medical University Vienna, Vienna, Austria.
Marcus G SeidelResearch Unit Pediatric Hematology and Immunology, Division of Pediatric Hematology-Oncology, Department of Pediatrics and Adolescent Medicine, Medical University Graz, Graz, Austria.
Heinz JacobsDivision of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Mirjam van der BurgLaboratory for Immunology, Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
Leiden University Medical Center · NLErasmus MC · NLErasmus MC - Sophia Children’s Hospital · NLHaga Hospital · NLInstitut Gustave Roussy · FRMedical University of Graz · ATMedical University of Vienna · ATOlgahospital · DEPoznan University of Medical Sciences · PLThe Netherlands Cancer Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The generation of high-affinity antibodies depends on somatic hypermutation (SHM). SHM is initiated by the activation-induced cytidine deaminase (AID), which generates uracil (U) lesions in the B-cell receptor (BCR) encoding genes. Error-prone processing of U lesions creates a typical spectrum of point mutations during SHM. The aim of this study was to determine the molecular mechanism of SHM in humans; currently available knowledge is limited by the number of mutations analyzed per patient. We collected a unique cohort of 10 well-defined patients with bi-allelic mutations in genes involved in base excision repair (BER) (

Indexed as

DNA Mismatch RepairDNA RepairSomatic Hypermutation, ImmunoglobulinB-LymphocytesCase-Control StudiesDNA-Binding ProteinsHumansMutationReceptors, Antigen, B-CellDNA-Binding ProteinsReceptors, Antigen, B-Cellbase excision repair (BER)B-cell receptorB cellsconstitutional mismatch repair deficiency (CMMRD)DNA repairimmunoglobulinmismatch repair (MMR)somatic hypermutation

Identifiers

PMID31507588
PMCPMC6718458
OpenAlexW2964737772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.