Evidence map›Paper›PMID 31507550›Full record

ArticleFrontiers in microbiology2019

The RpoS Gatekeeper in

Melissa J Caimano, Ashley M Groshong, Alexia Belperron, Jialing Mao, Kelly L Hawley, Amit Luthra, Danielle E Graham, Christopher G Earnhart, Richard T Marconi, Linda K Bockenstedt and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 101 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. TheInfection and immunity · 2026
    Article
  5. ThemBio · 2026
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  6. The BosR Is Back!Molecular microbiology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Virulence Regulation inMicroorganisms · 2025
    Review
  14. Borrelia surface proteins: new horizons in Lyme disease diagnosis.Applied microbiology and biotechnology · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Infection and immunity · 2025
    Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Melissa J CaimanoDepartment of Medicine, UConn Health, Farmington, CT, United States.
Ashley M GroshongDepartment of Medicine, UConn Health, Farmington, CT, United States.
Alexia BelperronDepartment of Internal Medicine, Section of Rheumatology, Allergy and Immunology, Yale School of Medicine, Yale University, New Haven, CT, United States.
Jialing MaoDepartment of Internal Medicine, Section of Rheumatology, Allergy and Immunology, Yale School of Medicine, Yale University, New Haven, CT, United States.
Kelly L HawleyDepartment of Pediatrics, UConn Health, Farmington, CT, United States.
Amit LuthraDepartment of Medicine, UConn Health, Farmington, CT, United States.
Danielle E GrahamDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Christopher G EarnhartDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA, United States.
Richard T MarconiDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA, United States.
Linda K BockenstedtDepartment of Internal Medicine, Section of Rheumatology, Allergy and Immunology, Yale School of Medicine, Yale University, New Haven, CT, United States.
Jon S BlevinsDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Justin D RadolfDepartment of Medicine, UConn Health, Farmington, CT, United States.
UConn Health · USYale University · USUniversity of Arkansas for Medical Sciences · USVirginia Commonwealth University Medical Center · USConnecticut Children's Medical Center · US

Funding

Study of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5M
RpoS Regulation of Borrelia burgdorferi Genes in vivoR01AI029735 · NIAID · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI CAIMANO, MELISSA J, RADOLF, JUSTIN D · 1990 to 2022
$10.7M
Pilot Grant ProgramP30GM145393 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI MARK S SMELTZER · 2022 to 2026
$7.6M
The University of Arkansas for Medical Sciences Initiative for Maximizing Student Development ProgramR25GM083247 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI MCGEHEE, ROBERT E, THOMAS, BILLY R · 2009 to 2023
$5.4M
RpoS-mediated virulence regulation in Borrelia burgdorferiR01AI087678 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI BLEVINS, JON SCOTT · 2010 to 2014
$1.8M
Essential role of Hk1/Rrp1 TCS for survival of Borrelia burgdorferi in ticksR21AI126146 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CAIMANO, MELISSA J · 2016 to 2017
$439k
Identification of genes required by Leptospira interrogans for mammalian host adaptation and/or persistence in the rat modelR21AI128379 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CAIMANO, MELISSA J · 2017 to 2018
$439k
Rrp2-dependent gene regulation in Borrelia burgdorferiR21AI119532 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI BLEVINS, JON SCOTT · 2015 to 2016
$403k
NIAID NIH HHS R01 AI029735NIAID NIH HHS R01 AI087678NIAID NIH HHS R21 AI119532NIAID NIH HHS R21 AI126146NIAID NIH HHS R21 AI128379NIGMS NIH HHS P20 GM103625NIGMS NIH HHS P30 GM145393NIGMS NIH HHS R25 GM083247
6 · The paper itself

Abstract

Maintenance of

Indexed as

Borrelia burgdorferigene regulationhost adaptationLyme diseasepersistencerpoSsigma factorvector borne disease

Identifiers

PMID31507550
PMCPMC6719511
OpenAlexW2964596603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.