ReviewFrontiers in microbiology2019
Discovery and Therapeutic Targeting of Differentiated Biofilm Subpopulations.
Review in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Temperature-dependent reprogramming of virulence traits duringbioRxiv : the preprint server for biology · 2026Article
- Biofilm Formation and the Pore ProteinsAntibiotics (Basel, Switzerland) · 2026Article
- Long-term control ofFrontiers in oral health · 2026Article
- Resistance profiles of fastidious oral anaerobes and other periodontal species by multipoint inoculator: anFrontiers in dental medicine · 2026Article
- Antimicrobial, antibiofilm, cytotoxicity, and anti-DNA topoisomerase activity of Streptomyces sp. 22SH with ADME and in silico study.BMC microbiology · 2025Article
- Bacterial Biofilms-A Threat to Biliary Stents, Understanding Their Formation, Clinical Consequences and Management.Medicina (Kaunas, Lithuania) · 2025Review
- Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities.Clinical microbiology reviews · 2024Review
- The phototrophic purple non-sulfur bacteria Rhodomicrobium spp. are novel chassis for bioplastic production.Microbial biotechnology · 2024Article
- Electroactive biofilms: how microbial electron transfer enables bioelectrochemical applications.Journal of industrial microbiology & biotechnology · 2022Review
- Lysis-Hi-C as a method to study polymicrobial communities and eDNA.Molecular ecology resources · 2022Article
- Article
- Haem toxicity provides a competitive advantage to the clinically relevantMicrobiology (Reading, England) · 2021Article
- Impact of temperature-dependent phage expression on Pseudomonas aeruginosa biofilm formation.NPJ biofilms and microbiomes · 2021Article
- Interspecies Metabolic Complementation in Cystic Fibrosis Pathogens via Purine Exchange.Pathogens (Basel, Switzerland) · 2021Article
- The Impact of Intraspecies and Interspecies Bacterial Interactions on Disease Outcome.Pathogens (Basel, Switzerland) · 2021Review
- Pseudomonas aeruginosa polymicrobial interactions during lung infection.Current opinion in microbiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The association of microorganisms into biofilms produces functionally organized microbial structures that promote community survival in a wide range of environments. Much like when individual cells within a multicellular organism express different genes from the same DNA blueprint, individual microbial cells located within different regions of a biofilm structure can exhibit distinct genetic programs. These spatially defined regions of physiologically differentiated cells are reminiscent of the role of tissues in multicellular organisms, with specific subpopulations in the microbial community serving defined roles to promote the overall health of the biofilm. The functions of these subpopulations are quite diverse and can range from dormant cells that can withstand antibiotic onslaughts to cells actively producing extracellular polymeric substances providing integrity to the entire community. The purpose of this review is to discuss the diverse roles of subpopulations in the stability and function of clonal biofilms, the methods for studying these subpopulations, and the ways these subpopulations can potentially be exploited for therapeutic intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.