Evidence map›Paper›PMID 31507525›Full record

ArticleFrontiers in neurology2019

Post-stroke Depression Increases Disability More Than 15% in Ischemic Stroke Survivors: A Case-Control Study.

Stefano Paolucci, Marco Iosa, Paola Coiro, Vincenzo Venturiero, Anna Savo, Domenico De Angelis, Giovanni Morone

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06782321 (Centering Emotional Recovery Post-Stroke), which is not on this map. Cited by 51 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06782321 narecruitingnot on this mapstarted 2025, after this paper: background citation

Centering Emotional Recovery Post-Stroke

TypeinterventionalSponsorMedical University of South CarolinaRan2025 to 2027Enrolled80ConditionsStroke, Mental Health Wellness 1Armsmodified Cognitive Behavioral Therapy (mCBT), Occupational or Speech Therapy
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  6. Motivation as a Measurable Outcome in Stroke Rehabilitation: A Systematic Review of the Literature.International journal of environmental research and public health · 2023
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  10. Health risk factors in Australian Stroke Survivors: A latent class analysis.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stefano PaolucciFondazione Santa Lucia-IRCCS, Rome, Italy.
Marco IosaFondazione Santa Lucia-IRCCS, Rome, Italy.
Paola CoiroFondazione Santa Lucia-IRCCS, Rome, Italy.
Vincenzo VenturieroFondazione Santa Lucia-IRCCS, Rome, Italy.
Anna SavoFondazione Santa Lucia-IRCCS, Rome, Italy.
Domenico De AngelisFondazione Santa Lucia-IRCCS, Rome, Italy.
Giovanni MoroneFondazione Santa Lucia-IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed a retrospective, case-control study in consecutive ischemic stroke patients admitted to our stroke rehabilitation unit. Patients were matched for severity of neurological impairment (evaluated with the Canadian Neurological Scale, CNS), age (difference within 1 year), and onset admission interval (difference within 3 days). Participants were divided into two subgroups according to the presence or absence of PSD. Aim was to assess the specific influence of post-stroke depression (PSD) and antidepressant treatment on both basal functional status and rehabilitation outcomes. All PSD patients were treated primarily with serotoninergic antidepressants (AD). The final sample included 280 patients with depression (out of 320 found in a whole case series of 993 ischemic patients, i.e., 32.25%) and 280 without depression. Forty patients with depression were excluded because they had a history of severe psychiatric illness or aphasia, with a severe comprehension deficit. On one hand, PSD patients obtained lower Barthel Index (BI) and Rivermead Mobility Index (RMI) scores at both admission and discharge, with minor effectiveness of rehabilitative treatment and longer length of stay; on the other hand, this group had a lower percentage of dropouts. Lastly, PSD patients showed a different functional outcome, based on their response to antidepressant therapy, that was significantly better in responders than in non-responders (13.13%). Our results confirm the unfavorable influence of PSD on functional outcome, despite pharmacological treatment.

Indexed as

antidepressantsdepressionfunctional outcomerehabilitationstroke

Identifiers

PMID31507525
PMCPMC6718567

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.