ArticleFrontiers in neurology2019
Parcellation of the Hippocampus Using Resting Functional Connectivity in Temporal Lobe Epilepsy.
Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 45 citations in OpenAlex.
- Abnormal functional connectivity patterns in temporal lobe epilepsy-An international ENIGMA-epilepsy study.Epilepsia open · 2026Article
- The Development of Hippocampal-Cortical Functional Connectivity in Infants and Toddlers.Human brain mapping · 2026Article
- Cortico-hippocampal networks underpin verbal memory encoding in temporal lobe epilepsy.Brain communications · 2025Article
- Sleep links hippocampal propensity for epileptiform activity to its viscerosensory inputs.Frontiers in neuroscience · 2025Article
- Longitudinal hippocampal axis in large-scale cortical systems underlying development and episodic memory.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Hippocampal anterior- posterior shift in childhood and adolescence.Progress in neurobiology · 2023Article
- Impaired orienting function detected through eye movements in patients with temporal lobe epilepsy.Frontiers in neuroscience · 2023Article
- Schemas provide a scaffold for neocortical integration of new memories over time.Nature communications · 2022Article
- Episodic memory network connectivity in temporal lobe epilepsy.Epilepsia · 2022Article
- Data-Driven Clustering of Functional Signals Reveals Gradients in Processing Both within the Anterior Hippocampus and across Its Long Axis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Contextual Expectations Shape Cortical Reinstatement of Sensory Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Dynamic functional connectivity in modular organization of the hippocampal network marks memory phenotypes in temporal lobe epilepsy.Human brain mapping · 2022Article
- Medial temporal lobe contributions to resting-state networks.Brain structure & function · 2022Article
- The many dimensions of human hippocampal organization and (dys)function.Trends in neurosciences · 2021Review
- Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain.PLoS biology · 2021Article
- Functional connectivity of the hippocampus and its subfields in resting-state networks.The European journal of neuroscience · 2021Article
- An exploratory study into the influence of laterality and location of hippocampal sclerosis on seizure prognosis and global cortical thinning.Scientific reports · 2021Article
- Functional parcellation of the hippocampus by semi-supervised clustering of resting state fMRI data.Scientific reports · 2020Article
- Single voxel autocorrelation reflects hippocampal function in temporal lobe epilepsy.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that the connectivity of the hippocampus to other regions of the default mode network (DMN) is a strong indicator of memory ability in people with temporal lobe epilepsy (TLE). Recent work in the cognitive neuroscience literature has suggested that the anterior and posterior aspects of the hippocampus have distinct connections to the rest of the DMN and may support different memory operations. Further, structural analysis of epileptogenic hippocampi has found greater atrophy, characterized by mesial temporal sclerosis, in the anterior region of the hippocampus. Here, we used resting state FMRI data to parcellate the hippocampus according to its functional connectivity to the rest of the brain in people with left lateralized TLE (LTLE) and right lateralized TLE (RTLE), and in a group of neurologically healthy controls. We found similar anterior and posterior compartments in all groups. However, there was weaker connectivity of the epileptogenic hippocampus to multiple regions of the DMN. Both TLE groups showed reduced connectivity of the posterior hippocampus to key hubs of the DMN, the posterior cingulate cortex (PCC) and the medial pre-frontal cortex (mPFC). In the LTLE group, the anterior hippocampus also showed reduced connectivity to the DMN, and this effect was influenced by the presence of mesial temporal sclerosis. When we explored brain-behavior relationships, we found that reduced connectivity of the left anterior hippocampus to the DMN hubs related to poorer verbal memory ability in people with LTLE, and reduced connectivity of the right posterior hippocampus to the PCC related to poorer visual memory ability in those with RTLE. These findings may inform models regarding functional distinctions of the hippocampal anteroposterior axis.
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