ReviewFrontiers in psychiatry2019
Rewiring the Addicted Brain Through a Psychobiological Model of Physical Exercise.
Review in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Effects of exercise on executive function in individuals with drug addiction: a systematic review and three-level meta-analysis.Frontiers in sports and active living · 2025Pooled it
- Effectiveness of exercise as an intervention for internet addiction in adolescents: a meta-analysis.PeerJ · 2025Pooled it
- Exercise and Brain Health in Postmenopausal Women: A Review of Cognitive Benefits, Mechanisms, and Neurodegeneration Prevention.NeuroSci · 2026Review
- The Dose-Response Relationship Between Leisure-Time Physical Activity and Smartphone Addiction in First-Year Tehran University Students: A Cross-Sectional Study.Health science reports · 2026Article
- Effects of Tai Chi on attentional bias in men with methamphetamine use disorder.NPJ science of learning · 2026Article
- Aerobic exercise for substance use disorders: therapeutic effects and underlying mechanisms.Frontiers in medicine · 2026Review
- A Review of Exercise Interventions for Rehabilitation in Drug-Dependent Individuals.Addiction biology · 2025Review
- The interplay between executive functions and updating predictive representations.Scientific reports · 2025Article
- Effects of acute and chronic exercise on working memory in healthy adults. An experimental investigation.Frontiers in psychology · 2025Article
- Article
- Brain-derived neurotrophic factor serum levels as a candidate biomarker for withdrawal in crack heroin dependence.Substance abuse treatment, prevention, and policy · 2024Article
- Physical Exercise to Redynamize Interoception in Substance use Disorders.Current neuropharmacology · 2024Article
- The Role of Physical Exercise in Opioid Substitution Therapy: Mechanisms of Sequential Effects.International journal of molecular sciences · 2023Review
- Effects of Acute Moderate- and High-Intensity Aerobic Exercise on Oxygenation in Prefrontal Cortex of Male Methamphetamine-Dependent Patients.Frontiers in psychology · 2022Article
- The impact of intermittent exercise on mouse ethanol drinking and abstinence-associated affective behavior and physiology.Alcoholism, clinical and experimental research · 2022Article
- The effect of high-intensity interval training on cognitive function in patients with substance use disorder: Study protocol for a two-armed randomized controlled trial.Frontiers in sports and active living · 2022Article
- The effects of substance use and physical activity on cognition: The impact of incongruent health behaviors.Drug and alcohol dependence · 2021Article
- Effects of exercise programs on neuroelectric dynamics in drug addiction.Cognitive neurodynamics · 2021Article
- Short Bouts of Physical Activity Are Associated with Reduced Smoking Withdrawal Symptoms, but Perceptions of Intensity May Be the Key.Healthcare (Basel, Switzerland) · 2020Article
- Community-Based Yoga for Women Undergoing Substance Use Disorder Treatment: A Descriptive Study.International journal of yogaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug addiction is a worldwide public health problem, resulting from multiple phenomena, including those both social and biological. Chronic use of psychoactive substances has been shown to induce structural and functional changes in the brain that impair cognitive control and favor compulsive seeking behavior. Physical exercise has been proven to improve brain function and cognition in both healthy and clinical populations. While some studies have demonstrated the potential benefits of physical exercise in treating and preventing addictive behaviors, few studies have investigated its cognitive and neurobiological contributions to drug-addicted brains. Here, we review studies in humans using cognitive behavioral responses and neuroimaging techniques, which reveal that exercise can be an effective auxiliary treatment for drug addictive disorders. Moreover, we describe the neurobiological mechanisms by which exercise-induced neuroplasticity in the prefrontal cortex improves executive functions and may decrease compulsive behaviors in individuals prone to substance use disorders. Finally, we propose an integrative cognitive-psychobiological model of exercise for use in future research in drug addiction and practical guidance in clinical settings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.