Evidence map›Paper›PMID 31507452›Full record

ArticleFrontiers in physiology2019

Reintroducing Heart Sounds for Early Detection of Acute Myocardial Ischemia in a Porcine Model - Correlation of Acoustic Cardiography With Gold Standard of Pressure-Volume Analysis.

Marco Luciani, Matteo Saccocci, Shingo Kuwata, Nikola Cesarovic, Miriam Lipiski, Patricia Arand, Peter Bauer, Andrea Guidotti, Evelyn Regar, Paul Erne and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Health Monitoring via Heart, Breath, and Korotkoff Sounds by Wearable Piezoelectret Patches.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Marco LucianiDepartment of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.
Matteo SaccocciDepartment of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.
Shingo KuwataDepartment of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.
Nikola CesarovicDivision of Surgical Research, University Hospital Zurich, Zurich, Switzerland.
Miriam LipiskiDivision of Surgical Research, University Hospital Zurich, Zurich, Switzerland.
Patricia ArandVisCardia, Inc., Portland, OR, United States.
Peter BauerVisCardia, Inc., Portland, OR, United States.
Andrea GuidottiDepartment of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.
Evelyn RegarDepartment of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.
Paul ErneFaculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
Michel ZuberDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Francesco MaisanoDepartment of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.
University Hospital of Zurich · CHUniversità della Svizzera italiana · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcoustic cardiography is a hybrid technique that couples heart sounds recording with ECG providing insights into electrical-mechanical activity of the heart in an unsupervised, non-invasive and inexpensive manner. During myocardial ischemia hemodynamic abnormalities appear in the first minutes and we hypothesize a putative diagnostic role of acoustic cardiography for prompt detection of cardiac dysfunction for future patient management improvement. METHODS AND

resultsTen female Swiss large white pigs underwent permanent distal coronary occlusion as a model of acute myocardial ischemia. Acoustic cardiography analyses were performed prior, during and after coronary occlusion. Pressure-volume analysis was conducted in parallel as an invasive method of hemodynamic assessment for comparison. Similar systolic and diastolic intervals obtained with the two techniques were significantly correlated [Q to min dP/dt vs. Q to second heart sound (

conclusionIn the rapidly evolving setting of acute myocardial ischemia, acoustic cardiography provided meaningful insights of mechanical dysfunction in a prompt and non-invasive manner. These findings should propel interest in resurrecting this technique for future translational studies as well as reconsidering its reintroduction in the clinical setting.

Indexed as

acute coronary syndromeacute myocardial ischemiaanimal modelheart soundhemodynamics

Identifiers

PMID31507452
PMCPMC6713932
OpenAlexW2967484121

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.