ArticleFrontiers in physiology2019
Effects of Prolonged Head-Down Bed Rest on Cardiac and Vascular Baroreceptor Modulation and Orthostatic Tolerance in Healthy Individuals.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- The potential for autonomic neuromodulation to reduce perioperative complications and pain: a systematic review and meta-analysis.British journal of anaesthesia · 2022Pooled it
- Monitoring stress and allostatic load in first responders and tactical operators using heart rate variability: a systematic review.BMC public health · 2021Pooled it
- Trial
- Frequency and characteristics of multi-domain autonomic dysfunction in patients with spontaneous intracranial hypotension.Headache · 2026Article
- Dose-dependent effects of graded altered gravity during hypovolaemia on central haemodynamics and cardiovascular autonomic regulation.Experimental physiology · 2026Article
- Targeted autonomic testing for radiation‑induced baroreflex failure in head and neck cancer survivors: index case and early program experience.Cardio-oncology (London, England) · 2026Article
- Three-week dry immersion results in a more severe impairment of cardiac baroreflex than head-down bed rest of the same duration.European journal of applied physiology · 2026Article
- The effects of bed rest on cardiometabolic health: A systematic review and meta-analysis.Experimental physiology · 2026Article
- Autonomic Dysfunction and Low Cardio-Respiratory Fitness in Long-Term Post-COVID-19 Syndrome.Biomedicines · 2025Article
- Attenuated cardiac autonomic function in patients with long-COVID with impaired orthostatic hemodynamics.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Alterations in blood pressure dependent activation of leg muscles during standing following bed rest mimic those observed with ageing.Frontiers in physiology · 2025Article
- Prevalence and Outcomes of Orthostatic Hypotension in Hemorrhagic Stroke Patients During Hospitalization.Neurology international · 2024Article
- Retinal blood vessel diameter changes with 60-day head-down bedrest are unaffected by antioxidant nutritional cocktail.NPJ microgravity · 2024Article
- Cardiopulmonary deconditioning and plasma volume loss are not sufficient to provoke orthostatic hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Effect of artificial gravity on neurocognitive performance during head-down tilt bedrest.NPJ microgravity · 2024Article
- Long-COVID autonomic syndrome in working age and work ability impairment.Scientific reports · 2024Observational
- Detecting Orthostatic Intolerance in Long COVID in a Clinic Setting.International journal of environmental research and public health · 2023Article
- Moderate Aerobic Exercise Reduces the Detrimental Effects of Hypoxia on Cardiac Autonomic Control in Healthy Volunteers.Journal of personalized medicine · 2023Article
- Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest.Frontiers in cardiovascular medicine · 2023Article
- Orthostatic intolerance: a frailty marker for older adults.European geriatric medicine · 2022Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
Orthostatic intolerance commonly occurs after prolonged bed rest, thus increasing the risk of syncope and falls. Baroreflex-mediated adjustments of heart rate and sympathetic vasomotor activity (muscle sympathetic nerve activity - MSNA) are crucial for orthostatic tolerance. We hypothesized that prolonged bed rest deconditioning alters overall baroreceptor functioning, thereby reducing orthostatic tolerance in healthy volunteers. As part of the European Space Agency Medium-term Bed Rest protocol, 10 volunteers were studied before and after 21 days of -6° head down bed rest (HDBR). In both conditions, subjects underwent ECG, beat-by-beat blood pressure, respiratory activity, and MSNA recordings while supine (REST) and during a 15-min 80° head-up tilt (TILT) followed by a 3-min -10 mmHg stepwise increase of lower body negative pressure to pre-syncope. Cardiac baroreflex sensitivity (cBRS) was obtained in the time (sequence method) and frequency domain (spectrum and cross-spectrum analyses of RR interval and systolic arterial pressure - SAP, variability). Baroreceptor modulation of sympathetic discharge activity to the vessels (sBRS) was estimated by the slope of the regression line between the percentage of MSNA burst occurrence and diastolic arterial pressure. Orthostatic tolerance significantly decreased after HDBR (12 ± 0.6 min) compared to before (21 ± 0.6 min). While supine, heart rate, SAP, and cBRS were unchanged before and after HDBR, sBRS gain was slightly depressed after than before HDBR (sBRS: -6.0 ± 1.1 versus -2.9 ± 1.5 burst% × mmHg
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.