Evidence map›Paper›PMID 31507403›Full record

ArticleFrontiers in aging neuroscience2019

Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells

Aimi Syamima Abdul Manap, Amelia Cheng Wei Tan, Weng Hhin Leong, Adeline Yoke Yin Chia, Shantini Vijayabalan, Aditya Arya, Eng Hwa Wong, Farzana Rizwan, Umesh Bindal, Shajan Koshy and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 3 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Curcumin-Piperine Self-Nanoemulsifying Delivery inPharmaceuticals (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. The Role of Oxidative Stress in Trisomy 21 Phenotype.Cellular and molecular neurobiology · 2023
    Review
  18. Review
  19. Article
  20. Black Pepper (Antioxidants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Aimi Syamima Abdul ManapSchool of Biosciences, Faculty of Health and Sciences, Taylor's University, Subang Jaya, Malaysia.
Amelia Cheng Wei TanSchool of Biosciences, Faculty of Health and Sciences, Taylor's University, Subang Jaya, Malaysia.
Weng Hhin LeongSchool of Biosciences, Faculty of Health and Sciences, Taylor's University, Subang Jaya, Malaysia.
Adeline Yoke Yin ChiaSchool of Biosciences, Faculty of Health and Sciences, Taylor's University, Subang Jaya, Malaysia.
Shantini VijayabalanSchool of Pharmacy, Faculty of Health and Sciences, Taylor's University, Subang Jaya, Malaysia.
Aditya AryaSchool of Medicine, Faculty of Health and Sciences, Taylor's University, Subang Jaya, Malaysia.
Eng Hwa WongSchool of Medicine, Faculty of Health and Sciences, Taylor's University, Subang Jaya, Malaysia.
Farzana RizwanSchool of Medicine, Faculty of Health and Sciences, Taylor's University, Subang Jaya, Malaysia.
Umesh BindalSchool of Medicine, Faculty of Health and Sciences, Taylor's University, Subang Jaya, Malaysia.
Shajan KoshySchool of Medicine, Faculty of Health and Sciences, Taylor's University, Subang Jaya, Malaysia.
Priya MadhavanSchool of Medicine, Faculty of Health and Sciences, Taylor's University, Subang Jaya, Malaysia.
Taylor's University · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hallmarks of Alzheimer's disease (AD) pathology include acetylcholine (ACh) deficiency and plaque deposition. Emerging studies suggest that acetylcholinesterase (AChE) may interact with amyloid β (Aβ) to promote aggregation of insoluble Aβ plaques in brains of patients. Current therapeutic options available for AD patients, such as AChE inhibitors, provide only symptomatic relief. In this study, we screened four natural compounds believed to harbor cognitive benefits-curcumin, piperine, bacoside A, and chebulinic acid. In the first section, preliminary screening through computational molecular docking simulations gauged the suitability of the compounds as novel AChE inhibitors. From here, only compounds that met the

Indexed as

acetylcholinesteraseAlzheimer’s diseaseamyloid betacurcuminpiperine

Identifiers

PMID31507403
PMCPMC6718453
OpenAlexW2964000120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.