Trial reportBrain and behavior2019
A pilot study on high amplitude low frequency-music impulse stimulation as an add-on treatment for depression.
Trial report in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Music intervention for sleep quality in critically ill and surgical patients: a meta-analysis.BMJ open · 2021Pooled it
- Effects of music therapy on depression: A meta-analysis of randomized controlled trials.PloS one · 2020Pooled it
- Music and low-frequency vibrations for the treatment of chronic musculoskeletal pain in elderly: A pilot study.PloS one · 2021Trial
- A pilot study on high amplitude low frequency-music impulse stimulation as an add-on treatment for depression.Brain and behavior · 2019Trial
- Can Phonotherapy Serve as an Adjunct Treatment for Acute and Chronic Stroke? A Preliminary Report.Healthcare (Basel, Switzerland) · 2026Article
- The Relevance of Heart Rate Variability for Hypnotherapy and Psychotherapy.Brain sciences · 2026Review
- Psychophysiological effects of low-frequency sound mediated by room size, room shape, and stimulus duration.Frontiers in cognition · 2026Article
- Telecommunication technologies as a medium for music psychotherapy in educational settings.BMC psychology · 2025Article
- Effects of Vibroacoustic Stimulation on Psychological, Physiological, and Cognitive Stress.Sensors (Basel, Switzerland) · 2024Article
- Possible Mechanisms for the Effects of Sound Vibration on Human Health.Healthcare (Basel, Switzerland) · 2021Review
- Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Evolution and Emerging Trends in Depression Research From 2004 to 2019: A Literature Visualization Analysis.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHigh Amplitude Low Frequency-Music Impulse Stimulation (HALF-MIS) is a form of Vagus Nerve Stimulation (VNS). The aim of the study was to determine the feasibility, efficacy, and potential side effects of HALF-MIS, used as an add-on treatment for depression.
methodsThis is an open randomized controlled pilot study. Patients with depressive disorder were randomly allocated to either a HALF-MIS group with eight add-on HALF-MIS sessions (over a period of 3-4 weeks) or a control group which received treatment as usual. Seated in a specially designed chair() embedded with a transducer, their central nervous system was stimulated through the abdomen, () using music and vibration. Hamilton rating was performed. Side effects were registered.
resultsEighteen patients were randomized to the add-on treatment and 20 patients to the control group. Both groups show in Hamilton Depression Rating Scale (HDRS)-17 and in HDRS-6, although the HALF-MIS group had a greater decline of symptoms. This was a significant difference in intergroup analysis (p = .011, CI 95% for the HALF-MIS group 3.0588-8.5327 and CI 95% for the control group 0.2384-3.0). The (HDRS)-6 difference was also significant (p = .020, CI 95% for the HALF-MIS group 1.5911-5.0487 and for the control group -0.297 to 1.7058). No side effects were observed.
conclusionsHigh Amplitude Low Frequency-Music Impulse Stimulation treatment seems to give beneficial effect as an add-on treatment for depression. HALF-MIS appears to be a safe and effective add-on treatment for depression.
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