ArticleMolecular genetics & genomic medicine2019
The genetic polymorphisms of ZC3HC1 and SMARCA4 are associated with hypertension risk.
Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 18 citations in OpenAlex.
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- LDL-receptor gene polymorphism as a predictor of coronary artery disease: an Egyptian pilot study: relation to lipid profile and angiographic findings.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Article
- Bioinformatics Analysis of Next Generation Sequencing Data Identifies Molecular Biomarkers Associated With Type 2 Diabetes Mellitus.Clinical medicine insights. Endocrinology and diabetes · 2023Article
- Identifying shared genetic loci between coronavirus disease 2019 and cardiovascular diseases based on cross-trait meta-analysis.Frontiers in microbiology · 2022Article
- Nursing case management for people with hypertension: A randomized controlled trial protocol.Medicine · 2020Article
- The genetic polymorphisms of ZC3HC1 and SMARCA4 are associated with hypertension risk.Molecular genetics & genomic medicine · 2019Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIn this study, we aimed to evaluate the association between genetic variants of ZC3HC1 and SMARCA4 and hypertension risk in the Chinese Han population.
methodsThe Agena MassAssary platform was used to determine the genotypes of eight SNPs in ZC3HC1 and SMARCA4 from 350 hypertension patients and 483 healthy controls. Chi-squared tests and genetic model were used to evaluate the associations. Odds ratios and 95% confidence intervals were calculated using unconditional logistic regression. The statistical power of this study was estimated through the Power and Sample Size Calculation online software.
resultIn the genetic model analysis, we identified that the SNP of rs1464890 in ZC3HC1 was associated with a 0.68-fold decreased risk of hypertension in the codominant model and 0.65-fold decreased risk in the dominant model. Rs4507692 in ZC3HC1 was associated with a 0.69-fold decreased risk of hypertension in the codominant model and 0.66-fold decreased risk in the dominant model. The genotype "G/A-A/A" of rs11879293 and the genotype "G/T-T/T" of rs1122608 in SMARCA4 were significantly associated with decreasing the hypertension risk. In addition, the "A
conclusionThe present study suggested that ZC3HC1 and SMARCA4 polymorphism may conducive to play a protective role against the hypertension risk.
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