ArticleChemistry (Weinheim an der Bergstrasse, Germany)2019
Regioselective Glycosylation Strategies for the Synthesis of Group Ia and Ib Streptococcus Related Glycans Enable Elucidating Unique Conformations of the Capsular Polysaccharides.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Stereoselective Shi-type epoxidation with 3-oxo-4,6-RSC advances · 2024Article
- Borane-Trimethylamine Complex: A Versatile Reagent in Organic Synthesis.Molecules (Basel, Switzerland) · 2024Review
- Calibration of a serum reference standard for Group B streptococcal polysaccharide conjugate vaccine development using surface plasmon resonance.NPJ vaccines · 2023Article
- Synthetic Glycans to Improve Current Glycoconjugate Vaccines and Fight Antimicrobial Resistance.Chemical reviews · 2022Review
- Chemical Synthesis and Immunological Evaluation of Fragments of the Multiantennary Group-Specific Polysaccharide of Group BJACS Au · 2022Article
- Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments.Biochemical Society transactions · 2021Review
- Conformational Studies of Oligosaccharides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Review
- Structure-Guided Design of a Group B Streptococcus Type III Synthetic Glycan-Conjugate Vaccine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Glycan structures and their interactions with proteins. A NMR view.Current opinion in structural biology · 2020Review
- Regioselective Glycosylation Strategies for the Synthesis of Group Ia and Ib Streptococcus Related Glycans Enable Elucidating Unique Conformations of the Capsular Polysaccharides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
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Authors and funding
9 authors.
Funding
Abstract
Group B Streptococcus serotypes Ia and Ib capsular polysaccharides are key targets for vaccine development. In spite of their immunospecifity these polysaccharides share high structural similarity. Both are composed of the same monosaccharide residues and differ only in the connection of the Neu5Acα2-3Gal side chain to the GlcNAc unit, which is a β1-4 linkage in serotype Ia and a β1-3 linkage in serotype Ib. The development of efficient regioselective routes for GlcNAcβ1-3[Glcβ1-4]Gal synthons is described, which give access to different group B Streptococcus (GBS) Ia and Ib repeating unit frameshifts. These glycans were used to probe the conformation and molecular dynamics of the two polysaccharides, highlighting the different presentation of the protruding Neu5Acα2-3Gal moieties on the polysaccharide backbones and a higher flexibility of Ib polymer relative to Ia, which can impact epitope exposure.
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