Evidence map›Paper›PMID 31506900›Full record

ArticleMolecular neurobiology2020

Oxidative Stress and Lymphocyte Alterations in Chronic Relapsing Experimental Allergic Encephalomyelitis in the Rat Hippocampus and Protective Effects of an Ethanolamine Phosphate Salt.

Aranzazu Perianes-Cachero, María V T Lobo, Alberto M Hernández-Pinto, Rebeca Busto, Miguel Angel Lasunción-Ripa, Eduardo Arilla-Ferreiro, Lilian Puebla-Jiménez

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Oxidative Stress Markers in Multiple Sclerosis.International journal of molecular sciences · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aranzazu Perianes-CacheroGrupo de Neurobioquímica, Unidad de Bioquímica y Biología Molecular, Departamento de Biología de Sistemas, Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
María V T LoboDepartamento de Biomedicina y Biotecnología, Unidad de Biología Celular, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
Alberto M Hernández-PintoGrupo de Neurobioquímica, Unidad de Bioquímica y Biología Molecular, Departamento de Biología de Sistemas, Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
Rebeca BustoServicio de Bioquímica-Investigación, Hospital Ramón y Cajal, IRYCIS, Ctra. Colmenar Km 9, 28034, Madrid, Spain.
Miguel Angel Lasunción-RipaServicio de Bioquímica-Investigación, Hospital Ramón y Cajal, IRYCIS, Ctra. Colmenar Km 9, 28034, Madrid, Spain.
Eduardo Arilla-FerreiroGrupo de Neurobioquímica, Unidad de Bioquímica y Biología Molecular, Departamento de Biología de Sistemas, Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
Lilian Puebla-JiménezGrupo de Neurobioquímica, Unidad de Bioquímica y Biología Molecular, Departamento de Biología de Sistemas, Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain. lilian.puebla@uah.es.ORCID http://orcid.org/0000-0002-0681-3235

Funding

Ministerio de Ciencia e Innovación S2010/BMD-2423Ministerio de Ciencia e Innovación SAF2010-22277Ministerio de Ciencia e Innovación SAF2011-29951
6 · The paper itself

Abstract

Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) exhibits neuropathological and immunological dysfunctions similar to those found in multiple sclerosis (MS) and has been used as an animal model of MS. Inflammatory infiltrates and oxidative stress have been linked to the development of both diseases. Ethanolamine plasmalogen derivates have been shown to be powerful antioxidants and immunomodulators. Therefore, the objective of this study was to analyse inflammatory infiltrates, the state of the oxidative defences and the possible protective effects of calcium, magnesium and phosphate ethanolamine (EAP) in the CR-EAE rat hippocampus. To this aim, we evaluated, by immunohistochemistry, T cell infiltrates, Iba-1

Indexed as

Oxidative StressAnimalsApoptosisBody WeightCatalaseCD3 ComplexChronic DiseaseEncephalomyelitis, Autoimmune, ExperimentalEthanolaminesFeeding BehaviorGlutathioneGlutathione PeroxidaseGlutathione ReductaseHippocampusHypersensitivityLipid PeroxidationCatalaseCD3 ComplexEthanolaminesGlutathioneGlutathione PeroxidaseGlutathione ReductaseNeuroprotective AgentsphosphorylethanolamineSterolsSuperoxide DismutaseAntioxidant defencesCR-EAEEthanolamine phosphateHippocampusMultiple sclerosisOxidative stress

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.