Evidence map›Paper›PMID 31506867›Full record

ReviewSeminars in immunopathology2019

γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity.

Cuong Thach Nguyen, Emanual Maverakis, Matthias Eberl, Iannis E Adamopoulos

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in immunopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Innate Lymphocytes in Inflammatory Arthritis.Frontiers in immunology · 2020
    Review
  17. Strategies to Improve Outcomes in Psoriatic Arthritis.Current rheumatology reports · 2019
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Cuong Thach NguyenDepartment of Internal Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA, USA.
Emanual MaverakisDepartment of Dermatology, School of Medicine, University of California at Davis, Davis, CA, USA.
Matthias EberlDivision of Infection and Immunity, School of Medicine and Systems Immunity Research Institute, Cardiff University, Cardiff, CF14 4XN, UK.
Iannis E AdamopoulosDepartment of Internal Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA, USA. iannis@ucdavis.edu.
Cardiff University · GBShriners Hospitals for Children - Northern California · USTrường ĐH Nguyễn Tất Thành · VNUniversity of California, Davis · US

Funding

The IL-23/IL-17 Axis in Inflammatory ArthritisR01AR062173 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEVY, DAN · 2012 to 2025
$4.9M
Investigation and Development of New Therapeutic Avenues for SclerodermaDP2OD008752 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MAVERAKIS, EMANUAL M. · 2011 to 2016
$2.8M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases 1DP2OD008752Medical Research Council MR/N023145/1NIAMS NIH HHS R01 AR062173NIH HHS DP2 OD008752
6 · The paper itself

Abstract

The innate and adaptive arms of the immune system tightly regulate immune responses in order to maintain homeostasis and host defense. The interaction between those two systems is critical in the activation and suppression of immune responses which if unchecked may lead to chronic inflammation and autoimmunity. γδ T cells are non-conventional lymphocytes, which express T cell receptor (TCR) γδ chains on their surface and straddle between innate and adaptive immunity. Recent advances in of γδ T cell biology have allowed us to expand our understanding of γδ T cell in the dysregulation of immune responses and the development of autoimmune diseases. In this review, we summarize current knowledge on γδ T cells and their roles in skin and joint inflammation as commonly observed in rheumatic diseases.

Indexed as

Disease SusceptibilityAdaptive ImmunityAnimalsAutoimmunityHumansImmunity, InnateMiceReceptors, Antigen, T-Cell, gamma-deltaRheumatic DiseasesT-Lymphocyte SubsetsReceptors, Antigen, T-Cell, gamma-deltaAutoimmune diseasesBone remodelingPsoriatic arthritisSkin and joint inflammationT cell receptor (TCR)γδ T cells

Identifiers

PMID31506867
PMCPMC6815259
OpenAlexW2973037996

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.