SynthesisMetabolomics : Official journal of the Metabolomic Society2019
Metabolomics to reveal biomarkers and pathways of preterm birth: a systematic review and epidemiologic perspective.
Synthesis in Metabolomics : Official journal of the Metabolomic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Association of serum biomarkers of dietary purine intake with glycaemic control and risk of preterm birth: two prospective cohort studies among pregnant women.EBioMedicine · 2026Article
- Maternal metabolomic signatures for risk of preterm and early term birth in African American women.Nature health · 2026Article
- Integrated metagenomic and metabolomic profiling of spontaneous preterm birth in Chinese women.Frontiers in microbiology · 2026Article
- Stress-induced developmental plasticity and spontaneous preterm birth: A justice-oriented eco-evo-devo review.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Relationship between dietary protein intake and serum essential free amino acid concentrations in Japanese pregnant women: an observational study.BMC pregnancy and childbirth · 2025Observational
- Unraveling the Molecular Links between Fine Particulate Matter Exposure and Early Birth Risks in African American Mothers: A Metabolomics Study in the Atlanta African American Maternal-Child Cohort.Environmental science & technology · 2025Article
- An untargeted metabolome-wide association study of maternal perinatal tobacco smoking in newborn blood spots.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Taurine alleviates hyperuricemia-induced nephropathy in rats: insights from microbiome and metabolomics.Frontiers in nutrition · 2025Article
- Longitudinal urine metabolic profiling and gestational age prediction in human pregnancy.Briefings in bioinformatics · 2024Article
- Metabolomic Alterations Associated with Phthalate Exposures among Pregnant Women in Puerto Rico.Environmental science & technology · 2024Article
- Metabolomic analysis of the human placenta reveals perturbations in amino acids, purine metabolites, and small organic acids in spontaneous preterm birth.EXCLI journal · 2024Article
- The Role of Genetics in Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Roles of the Microbiota of the Female Reproductive Tract in Gynecological and Reproductive Health.Microbiology and molecular biology reviews : MMBR · 2022Review
- Prediction of gestational age using urinary metabolites in term and preterm pregnancies.Scientific reports · 2022Article
- Metabolomics: The Key to Unraveling the Role of the Microbiome in Visceral Pain Neurotransmission.Frontiers in neuroscience · 2022Review
- Associations of prenatal metabolomics profiles with early childhood growth trajectories and obesity risk in African Americans: the CANDLE study.International journal of obesity (2005) · 2021Article
- Comparison of dried blood spot and plasma sampling for untargeted metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Gestational age-dependent development of the neonatal metabolome.Pediatric research · 2021Article
- Sex Affects Human Premature Neonates' Blood Metabolome According to Gestational Age, Parenteral Nutrition, and Caffeine Treatment.Metabolites · 2021Article
- Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case-control discovery phase study.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionMost known risk factors for preterm birth, a leading cause of infant morbidity and mortality, are not modifiable. Advanced molecular techniques are increasingly being applied to identify biomarkers and pathways important in disease development and progression.
objectivesWe review the state of the literature and assess it from an epidemiologic perspective.
methodsPubMed, Embase, CINAHL, and Cochrane Central were searched on January 31, 2019 for original articles published after 1998 that utilized an untargeted metabolomic approach to identify markers of preterm birth. Eligible manuscripts were peer-reviewed and included original data from untargeted metabolomics analyses of maternal tissue derived from human studies designed to determine mechanisms and predictors of preterm birth.
resultsOf 2823 results, 14 articles met the inclusion requirements. There was little consistency in study design, outcome definition, type of biospecimen, or the inclusion of covariates and confounding factors, and few consistent associations with metabolites were identified in this review.
conclusionStudies to date on metabolomic predictors of preterm birth are highly heterogeneous in both methodology and resulting metabolite identification. There is an urgent need for larger studies in well-defined populations, to determine biomarkers predictive of preterm birth, and to reveal mechanisms and targets for development of intervention strategies.
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