ArticleSocial cognitive and affective neuroscience2019
The neural mechanisms of social reward in early psychosis.
Article in Social cognitive and affective neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Trust learning in the repeated trust game: A meta-analytic study.British journal of psychology (London, England : 1953) · 2026Pooled it
- The social cognitive and neural mechanisms that underlie social functioning in individuals with schizophrenia - a review.Translational psychiatry · 2023Pooled it
- Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-in-Schizophrenia 1 (DISC1).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Do interpersonal trust and social avoidance mediate the association between psychotic symptoms and social functioning in chronic schizophrenia patients?Frontiers in psychiatry · 2025Article
- Social identification and paranoia.Royal Society open science · 2024Article
- Value Representations of Spite Sensitivity in Psychosis on the Minnesota Trust Game.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- The effects of paranoia and dopamine on perception of cohesion and conspiracy: a pre-registered, double-blind, placebo-controlled experiment.Psychopharmacology · 2024Article
- Rethinking delusions: A selective review of delusion research through a computational lens.Schizophrenia research · 2022Review
- Neural, behavioural and real-life correlates of social context sensitivity and social reward learning during interpersonal interactions in the schizophrenia spectrum.The Australian and New Zealand journal of psychiatry · 2022Article
- Socioemotional mechanisms of loneliness in subclinical psychosis.Schizophrenia research · 2021Article
- Social reward, punishment, and prosociality in paranoia.Journal of abnormal psychology · 2021Article
- Grant Report on Social Reward Learning in SchizophreniaJournal of psychiatry and brain science · 2020Article
- Effect of Aggressive Experience in Female Syrian Hamsters on Glutamate Receptor Expression in the Nucleus Accumbens.Frontiers in behavioral neuroscience · 2020Article
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Authors and funding
6 authors.
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Abstract
In chronic psychosis, reduced trust is associated with a neural insensitivity to social reward and reduced theory of mind (ToM). Here we investigate whether these mechanisms could underlie emerging social impairments in early psychosis. Twenty-two participants with early psychosis and 25 controls (male, 13-19 years) participated in two interactive trust games against a cooperative and unfair partner. Region of interest neuroimaging analyses included right caudate, medial prefrontal cortex (mPFC) and right temporoparietal junction (rTPJ), involved in reward and ToM processing. Both groups showed similar levels of trust (i.e. investments). However, individuals with psychosis failed to activate the caudate differentially in response to cooperation and unfairness while making decisions to trust. During cooperative returns, patients showed reduced and controls increased caudate activation. Patients demonstrated greater rTPJ activation than controls, possibly pointing towards compensatory mechanisms. Effects were associated with Wechsler Abbreviated Scale of Intelligence vocabulary scores. No group differences emerged in mPFC activation. Early psychosis is associated with an aberrant neural sensitivity to social reward. This could foster reduced social motivation and social isolation. Absent behavioural differences in early, relative to chronic psychosis could indicate that trust is achieved through increased compensatory demand on ToM.
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