Evidence map›Paper›PMID 31506606›Full record

ArticleCell death and differentiation2020

βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.

Ainhoa Nieto, Makoto R Hara, Victor Quereda, Wayne Grant, Vanessa Saunders, Kunhong Xiao, Patricia H McDonald, Derek R Duckett

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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  10. Targets for protection and mitigation of radiation injury.Cellular and molecular life sciences : CMLS · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Ainhoa NietoDepartment of Cancer Physiology, Moffitt Cancer Center, Tampa, FL, 33612, USA.ORCID http://orcid.org/0000-0003-3881-2752
Makoto R HaraDepartment of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.
Victor QueredaDepartment of Drug Discovery, Moffitt Cancer Center, Tampa, FL, 33612, USA.
Wayne GrantDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USA.
Vanessa SaundersDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USA.
Kunhong XiaoDepartment of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.
Patricia H McDonaldDepartment of Cancer Physiology, Moffitt Cancer Center, Tampa, FL, 33612, USA. patsy.McDonald@moffitt.org.
Derek R DuckettDepartment of Drug Discovery, Moffitt Cancer Center, Tampa, FL, 33612, USA. derek.Duckett@moffitt.org.
Moffitt Cancer Center · USScripps Research Institute · USDuke Medical Center · USNovartis (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular DNA is constantly under threat from internal and external insults, consequently multiple pathways have evolved to maintain chromosomal fidelity. Our previous studies revealed that chronic stress, mediated by continuous stimulation of the β

Indexed as

DNA RepairAnimalsbeta-Arrestin 1Cell Line, TumorCell SurvivalDNA-Binding ProteinsDNA DamageHEK293 CellsHumansIntestinesMice, Inbred C57BLProtein BindingProtein Processing, Post-TranslationalRadiation, IonizingRadiation ToleranceTumor Suppressor p53-Binding Protein 1beta-Arrestin 1DNA-Binding ProteinsRAD18 protein, humanTP53BP1 protein, humanTrp53bp1 protein, mouseTumor Suppressor p53-Binding Protein 1Ubiquitin-Protein Ligases

Identifiers

PMID31506606
PMCPMC7206116
OpenAlexW2972769596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.