ArticleScientific reports2019
Role of POMC and AgRP neuronal activities on glycaemia in mice.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Autophagy in hypothalamic POMC and AgRP neurons: mechanisms and therapeutic implications for obesity.International journal of obesity (2005) · 2026Review
- Dual rescue mission: P-G3 dendrimer addresses ovarian and neuroendocrine roots of obesity-linked subfertility.Journal of advanced research · 2026Article
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.Metabolism: clinical and experimental · 2026Article
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.bioRxiv : the preprint server for biology · 2025Article
- The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Leptin signaling in POMC neurons regulates plasma leptin levels and is critical to mediate hypothalamic-pituitary-adrenal axis activation during fasting.Scientific reports · 2025Article
- G proteins of the GScience advances · 2025Article
- Brain-Body Communication in Glucose Metabolism.Advances in experimental medicine and biology · 2025Review
- Review
- Article
- Brain Defense of Glycemia in Health and Diabetes.Diabetes · 2024Review
- History and future of leptin: Discovery, regulation and signaling.Metabolism: clinical and experimental · 2024Review
- Methodology for Studying Hypothalamic Regulation of Feeding Behaviors.Methods and protocols · 2024Review
- Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome.Nature communications · 2024Article
- 27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior.Science advances · 2024Article
- Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.Signal transduction and targeted therapy · 2024Article
- Advanced neurobiological tools to interrogate metabolism.Nature reviews. Endocrinology · 2023Review
- Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance.Cell metabolism · 2023Article
- Article
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Leptin regulates both feeding and glycaemia primarily through its receptors expressed on agouti-related peptide (AgRP) and pro-opiomelanocortin-expressing (POMC) neurons; however, it is unknown whether activity of these neuronal populations mediates the regulation of these processes. To determine this, we injected Cre-dependent designer receptors exclusively activated by designer drugs (DREADD) viruses into the hypothalamus of normoglycaemic and diabetic AgRP-ires-cre and POMC-cre mice to chemogenetically activate or inhibit these neuronal populations. Despite robust changes in food intake, activation or inhibition of AgRP neurons did not affect glycaemia, while activation caused significant (P = 0.014) impairment in insulin sensitivity. Stimulation of AgRP neurons in diabetic mice reversed leptin's ability to inhibit feeding but did not counter leptin's ability to lower blood glucose levels. Notably, the inhibition of POMC neurons stimulated feeding while decreasing glucose levels in normoglycaemic mice. The findings suggest that leptin's effects on feeding by AgRP neurons are mediated by changes in neuronal firing, while the control of glucose balance by these cells is independent of chemogenetic activation or inhibition. The firing-dependent glucose lowering mechanism within POMC neurons is a potential target for the development of novel anti-diabetic medicines.
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Registered trials
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