Evidence map›Paper›PMID 31506465›Full record

ArticleScientific reports2019

Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1

Changzhao Li, Bharat Mishra, Mahendra Kashyap, Zhiping Weng, Shaida A Andrabi, Shahid M Mukhtar, Arianna L Kim, David R Bickers, Levy Kopelovich, Mohammad Athar

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Changzhao LiDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Bharat MishraDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Mahendra KashyapDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Zhiping WengDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Shaida A AndrabiDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-4083-1998
Shahid M MukhtarDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Arianna L KimDepartment of Dermatology, Columbia University, New York, NY, USA.
David R BickersDepartment of Dermatology, Columbia University, New York, NY, USA.
Levy KopelovichDepartment of Medicine, Weill Cornell Medical College, New York, NY, USA. kopelovichl@gmail.com.
Mohammad AtharDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA. mohammadathar@uabmc.edu.
University of Alabama at Birmingham · USColumbia University · USCornell University · USUniversity of Alabama at Birmingham Hospital · US

Funding

Translational and Precision Medicine Resources Core (TRAP)P30AR069632 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHRISTIANO, ANGELA M · 2016 to 2020
$3.9M
Mechanism-based abrogation of BCC pathogenesisR01ES020344 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BICKERS, DAVID RINSEY · 2012 to 2016
$1.8M
Chemoprevention of environmental UVB-induced skin cancer in immunosuppressed miceR01ES026219 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ATHAR, MOHAMMAD · 2016 to 2020
$1.7M
NIAMS NIH HHS P30 AR069632NIEHS NIH HHS R01 ES020344NIEHS NIH HHS R01 ES026219
6 · The paper itself

Abstract

The study of dominantly heritable cancers has provided insights about tumor development. Gorlin syndrome (GS) is an autosomal dominant disorder wherein affected individuals develop multiple basal cell carcinomas (BCCs) of the skin. We developed a murine model of Ptch1 haploinsufficiency on an ornithine decarboxylase (ODC) transgenic background (Ptch1

Indexed as

HaploinsufficiencyAnimalsComputational BiologyEnergy MetabolismGene Expression ProfilingHeterozygoteLipid MetabolismMiceMice, Inbred C57BLMice, TransgenicOrnithine DecarboxylasePatched-1 ReceptorPentose Phosphate PathwayPhenotypeSkinSkin NeoplasmsOrnithine DecarboxylasePatched-1 ReceptorPtch1 protein, mouse

Identifiers

PMID31506465
PMCPMC6737076
OpenAlexW2973176562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.