Evidence map›Paper›PMID 31506335›Full record

ArticleGenetics2019

Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in

Elisabeth A Marnik, J Heath Fuqua, Catherine S Sharp, Jesse D Rochester, Emily L Xu, Sarah E Holbrook, Dustin L Updike

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Review
  3. LOTUS-domain proteins activate Vasa to drive germ granule assembly.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Analysis ofComputational and structural biotechnology journal · 2024
    Article
  11. Article
  12. How germ granules promote germ cell fate.Nature reviews. Genetics · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Transgenerational Sterility of a TransgenicmicroPublication biology · 2024
    Article
  17. Review
  18. Article
  19. Review
  20. ATP-induced crosslinking of a biomolecular condensate.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Elisabeth A MarnikThe Mount Desert Island Biological Laboratory, Bar Harbor, Maine 04672.ORCID 0000-0002-5199-6835
J Heath FuquaThe Mount Desert Island Biological Laboratory, Bar Harbor, Maine 04672.
Catherine S SharpThe Mount Desert Island Biological Laboratory, Bar Harbor, Maine 04672.
Jesse D RochesterThe Mount Desert Island Biological Laboratory, Bar Harbor, Maine 04672.
Emily L XuThe Mount Desert Island Biological Laboratory, Bar Harbor, Maine 04672.
Sarah E HolbrookThe Mount Desert Island Biological Laboratory, Bar Harbor, Maine 04672.
Dustin L UpdikeThe Mount Desert Island Biological Laboratory, Bar Harbor, Maine 04672 dupdike@mdibl.org.ORCID 0000-0002-1745-3669
Mount Desert Island Biological Laboratory · USCollege of the Atlantic · USUniversity of Maine · USWilliam & Mary · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Frederic Xavier Bonnet · 2012 to 2026
$60.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
The function of germ granules in maintaining pluripotency in the C. elegans germlineR01GM113933 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI UPDIKE, DUSTIN LYNN · 2015 to 2023
$3.1M
Understanding germ cell pluripotency through an inducible P-granule degradation systemF32GM128248 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI MARNIK, ELISABETH ADKINS · 2018 to 2019
$125k
NIGMS NIH HHS F32 GM128248NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20 GM104318NIGMS NIH HHS R01 GM113933
6 · The paper itself

Abstract

Vasa homologs are ATP-dependent DEAD-box helicases, multipotency factors, and critical components that specify and protect the germline. They regulate translation, amplify piwi-interacting RNAs (piRNAs), and act as RNA solvents; however, the limited availability of mutagenesis-derived alleles and their wide range of phenotypes have complicated their analysis. Now, with clustered regularly interspaced short palindromic repeats (CRISPR/Cas9), these limitations can be mitigated to determine why protein domains have been lost or retained throughout evolution. Here, we define the functional motifs of GLH-1/Vasa in

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCOP9 Signalosome ComplexCytoplasmic GranulesDEAD-box RNA HelicasesEukaryotic Initiation Factor-3Germ CellsGlycineMutationProteasome Endopeptidase ComplexProtein BindingProtein DomainsATP dependent 26S proteaseCaenorhabditis elegans ProteinsCOP9 Signalosome ComplexDEAD-box RNA HelicasesEukaryotic Initiation Factor-3GLH-1 protein, C elegansGlycineProteasome Endopeptidase ComplexC. elegansDDX4germ granulesgermlineGLH-1PCI complexP granulesVasa

Identifiers

PMID31506335
PMCPMC6827368
OpenAlexW2972404439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.