Evidence map›Paper›PMID 31506296›Full record

ArticleThe Journal of biological chemistry2019

Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast.

Maria J Aristizabal, Kristy Dever, Gian Luca Negri, Mary Shen, Nicole Hawe, Joris J Benschop, Frank C P Holstege, Nevan J Krogan, Ivan Sadowski, Michael S Kobor

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Oxidative stress response pathways in fungi.Cellular and molecular life sciences : CMLS · 2022
    Review
  3. Article
  4. HJournal of fungi (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Maria J AristizabalCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Kristy DeverCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Gian Luca NegriCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver V5Z 1L3, British Columbia, Canada.ORCID 0000-0001-7722-8888
Mary ShenCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Nicole HaweDepartment of Biochemistry and Molecular Biology, Molecular Epigenetics, Life Sciences Institute, University of British Columbia, Vancouver V6T 1Z3, British Columbia, Canada.
Joris J BenschopPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
Frank C P HolstegePrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
Nevan J KroganDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158.
Ivan SadowskiDepartment of Biochemistry and Molecular Biology, Molecular Epigenetics, Life Sciences Institute, University of British Columbia, Vancouver V6T 1Z3, British Columbia, Canada.
Michael S KoborCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada msk@bcchr.ca.
University of British Columbia · CAPrincess Máxima Center · NLCanada's Michael Smith Genome Sciences Centre · CACanadian Institute for Advanced Research · CAUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fcp1 is a protein phosphatase that facilitates transcription elongation and termination by dephosphorylating the C-terminal domain of RNA polymerase II. High-throughput genetic screening and gene expression profiling of

Indexed as

Gene Expression Regulation, FungalOxidative StressCyclin-Dependent Kinase 8DNA-Binding ProteinsPeroxidasesPhosphoprotein PhosphatasesProtein StabilitySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsThioredoxinsTranscriptional ActivationTranscription Factorscarboxy-terminal domain phosphataseCyclin-Dependent Kinase 8DNA-Binding ProteinsPeroxidasesPhosphoprotein PhosphatasesSaccharomyces cerevisiae ProteinsSKN7 protein, S cerevisiaeSSN3 protein, S cerevisiaeThioredoxinsTranscription FactorsTRX2 protein, S cerevisiaeTsa1 protein, S cerevisiaeCdk8Fcp1gene regulationMediator complexoxidative stressRNA polymerase IISkn7transcriptiontranscription factortranscription regulationtranscription repressiontranscriptomicsyeast transcription

Identifiers

PMID31506296
PMCPMC6827322
OpenAlexW2973066563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.