ArticleAtencion primaria
[Anemia increases mortality risk associated with frailty or disability in older adults. The FRADEA Study].
Article in Atencion primaria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 26 citations in OpenAlex.
- Comparative estimation of the spread of acute diarrhea and dengue in India using statistical mathematical and deep learning models.Scientific reports · 2025Article
- Clinical Characteristics and Prognostic Impact of Short Physical Performance Battery in Hospitalized Patients with Acute Heart Failure-Results of the PROFUND-IC Registry.Journal of clinical medicine · 2023Article
- Novel dynamic fuzzy Decision-Making framework for COVID-19 vaccine dose recipients.Journal of advanced research · 2022Article
- Recent development for biomedical applications of magnetic nanoparticles.Inorganic chemistry communications · 2021Review
- Prevalence and prognostic value of the coexistence of anaemia and frailty in older patients with heart failure.ESC heart failure · 2021Observational
- Prevalence of Anemia and Its Association with Frailty, Physical Function and Cognition in Community-Dwelling Older Adults: Findings from the HOPE Study.The journal of nutrition, health & aging · 2021Article
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Authors and funding
6 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze if anemia increases 10-year mortality risk associated to frailty and disability in older adults.
designSubstudy of the FRADEA population-based concurrent cohort study (Frailty and dependence in Albacete), with a 10-year follow-up (2007-2017) in people older than 69years.
settingAlbacete city, Spain.
participantsOf the 993 participants included in the first wave, 790 were selected with valid data on function (frailty and disability), anemia and vital status at 10years. MAIN MEASUREMENTS: Anemia was defined according to the criteria of the World Health Organization (hemoglobin <13g/dL in men and <12g/dL in women). A functional classification variable was created, including frailty and disability, identifying four progressive functional levels: robust, prefrail, frail and disabled in basic activities of daily life, using frailty phenotype and Barthel index respectively. A new eight categories variable was constructed combining the four functional groups with the presence or absence of anemia. The association with mortality was determined by Kaplan-Meier and Cox proportional hazards analysis adjusted for age, sex, comorbidity, polypharmacy, institutionalization and creatinine.
resultsMean age was 79years and 59.6% were women. 393 participants (49.7%) died during the follow-up period. The median survival was 98.4months (interquartile range 61). The risk of mortality increased from the levels with better functionality to those with worse functionality, and for each subgroup it was higher in the participants with anemia. Prefrail without anemia HR [hazard ratio] 1.59 (95%CI 1.07-2.36) and with anemia HR 2.37 (95%CI 1.38-4.05). Frail without anemia HR 3.18 (95%CI 1.68-6.02) and with anemia HR 4.42 (95%CI 1.99-9.84). Disabled without anemia HR 3.81 (95%CI 2.45-5.84) and with anemia HR 5.48 (95%CI 3.43-8.76).
conclusionAnemia increases the risk of mortality associated with frailty and disability in older adults.
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