ArticleBMC veterinary research2019
Estrogen receptors genotypes and canine mammary neoplasia.
Article in BMC veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Is PTEN rs397510595 an Unexpected Guardian in Canine Mammary Neoplasia?International journal of molecular sciences · 2025Article
- Modelling the ageing dependence of cancer evolutionary trajectories.Nature reviews. Cancer · 2025Review
- Differential Expression of LHR and FSHR in Canine Mammary Tumors: Correlation with Malignancy and Spay Status.Veterinary sciences · 2025Article
- Concurrent primary splenic lymphoma and mammary gland tumour with polycystic ovaries in a dog.Veterinarni medicina · 2024Article
- Occurrence of mammary gland tumours in male dogs and its weak association with development of testicular tumours: a review.Journal of applied genetics · 2024Review
- Identification of SNP markers for canine mammary gland tumours in females based on a genome-wide association study - preliminary results.Journal of veterinary research · 2023Article
- Epidemiological Investigation of Canine Mammary Tumors in Mainland China Between 2017 and 2021.Frontiers in veterinary science · 2022Article
- Fucoxanthin Exerts Anti-Tumor Activity on Canine Mammary Tumor Cells via Tumor Cell Apoptosis Induction and Angiogenesis Inhibition.Animals : an open access journal from MDPI · 2021Article
- Mammary carcinoma arising in an adenoma in a ewe.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- Hormonal Carcinogenesis in Canine Mammary Cancer: Molecular Mechanisms of Estradiol Involved in Malignant Progression.Animals : an open access journal from MDPI · 2021Review
- A Statistical Analysis of Risk Factors and Biological Behavior in Canine Mammary Tumors: A Multicenter Study.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEstrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabolism and mechanism of action was recognized and associated with human breast cancer susceptibility, clinical features and progression. Although some genetic variations in canine ESR1 gene were reported, their influence in clinicopathological features and progression of canine mammary tumors has not been fully evaluated. This study aims to assess the influence of SNPs in ESR1 gene (rs397512133, rs397510462, rs851327560, rs397510612, rs852887655, rs852684753 and rs852398698) in canine mammary tumors characteristics and progression. A group of 155 non-neutered bitches with mammary tumors was included in the study. Follow-up information was assessed 24 months after surgery.
resultsGenetic profiles associated with a later onset of mammary tumors and less aggressive clinicopathological features, namely smaller tumor size (≤ 3 cm) with extensive tubular differentiation and low canine-adapted prognostic index (vet-NPI), were identified in this study.
conclusionsOur data suggest that the ESR1 genetic profile may help on the decision regarding the selection of individual tailored preventive measures against canine mammary tumors development, such as early neutering.
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