Evidence map›Paper›PMID 31505947›Full record

ArticleCirculation. Cardiovascular imaging2019

Regression of Left Ventricular Mass in Athletes Undergoing Complete Detraining Is Mediated by Decrease in Intracellular but Not Extracellular Compartments.

Peter P Swoboda, Pankaj Garg, Eylem Levelt, David A Broadbent, Ashkun Zolfaghari-Nia, A James R Foley, Graham J Fent, Pei G Chew, Louise A Brown, Christopher E Saunderson and 3 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Peter P SwobodaDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
Pankaj GargDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
Eylem LeveltDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
David A BroadbentDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
Ashkun Zolfaghari-NiaDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
A James R FoleyDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
Graham J FentDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
Pei G ChewDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
Louise A BrownDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
Christopher E SaundersonDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
Erica Dall'ArmellinaDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
John P GreenwoodDepartment of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).
Sven Plein
Leeds Teaching Hospitals NHS Trust · GB

Funding

British Heart Foundation FS/13/71/30378British Heart Foundation RG/16/1/32092
6 · The paper itself

Abstract

backgroundAthletic cardiac remodeling can occasionally be difficult to differentiate from pathological hypertrophy. Detraining is a commonly used diagnostic test to identify physiological hypertrophy, which can be diagnosed if hypertrophy regresses. We aimed to establish whether athletic cardiac remodeling assessed by cardiovascular magnetic resonance is mediated by changes in intracellular or extracellular compartments and whether this occurs by 1 or 3 months of detraining.

methodsTwenty-eight athletes about to embark on a period of forced detraining due to incidental limb bone fracture underwent clinical assessment, ECG, and contrast-enhanced cardiovascular magnetic resonance within a week of their injury and then 1 month and 3 months later.

resultsAfter 1 month of detraining, there was reduction in left ventricular (LV) mass (130±28 to 121±25 g;

conclusionsRegression of athletic LV hypertrophy can be detected after just 1 month of complete detraining and is mediated by a decrease in the intracellular myocardial compartment with no change in the extracellular compartment. Further studies are needed in athletes with overt and pathological hypertrophy to establish whether native T1 and extracellular volume fraction may complement electrocardiography, echocardiography, cardiopulmonary exercise testing, and genetic testing in predicting the outcome of detraining.

Indexed as

Cardiovascular DeconditioningVentricular RemodelingAdaptation, PhysiologicalAdolescentAdultAthletesContrast MediaElectrocardiographyEnglandFemaleHumansHypertrophy, Left VentricularMagnetic Resonance ImagingMaleMiddle AgedOrganometallic CompoundsContrast MediagadobutrolOrganometallic Compoundsathleteshypertrophymagnetic resonance imagingsports

Identifiers

PMID31505947
PMCPMC7099858
OpenAlexW2972950242

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.