Evidence map›Paper›PMID 31505859›Full record

ArticleCancers2019

XIAP as a Target of New Small Organic Natural Molecules Inducing Human Cancer Cell Death.

Diego Muñoz, Martina Brucoli, Silvia Zecchini, Adrian Sandoval-Hernandez, Gonzalo Arboleda, Fabian Lopez-Vallejo, Wilman Delgado, Matteo Giovarelli, Marco Coazzoli, Elisabetta Catalani and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Antitumor Alkaloids in Tibetan Corydalis: Chemical Diversity and Pharmacological Insights.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  5. Article
  6. Volatile Metabolites ofMolecules (Basel, Switzerland) · 2023
    Article
  7. A New Flavanone fromMolecules (Basel, Switzerland) · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Diego MuñozDepartamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 111321, Colombia. drmunozc@unal.edu.co.
Martina BrucoliTumour Cell Death Laboratory, Cancer Research UK Beatson Institute, G61 1BD Glasgow, UK. 2310786B@student.gla.ac.uk.
Silvia ZecchiniDepartment of Biomedical and Clinical Sciences "Luigi Sacco" (DIBIC), Università degli Studi di Milano, 20157 Milano, Italy. silvia.zecchini@unimi.it.
Adrian Sandoval-HernandezDepartamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 111321, Colombia. agsandovalh@unal.edu.co.
Gonzalo ArboledaGrupo de Muerte Celular, Instituto de Genética, Universidad Nacional de Colombia, Bogotá 111321, Colombia. gharboledab@unal.edu.co.
Fabian Lopez-VallejoDepartamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 111321, Colombia. fhlopezv@unal.edu.co.
Wilman DelgadoDepartamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 111321, Colombia. wadelgadoa@unal.edu.co.
Matteo GiovarelliDepartment of Biomedical and Clinical Sciences "Luigi Sacco" (DIBIC), Università degli Studi di Milano, 20157 Milano, Italy. matteo.giovarelli@unimi.it.
Marco CoazzoliDepartment of Biomedical and Clinical Sciences "Luigi Sacco" (DIBIC), Università degli Studi di Milano, 20157 Milano, Italy. marco.coazzoli@unimi.it.
Elisabetta CatalaniDepartment for Innovation in Biological, Agro-food and Forest systems (DIBAF), Università degli Studi della Tuscia, 01100 Viterbo, Italy. ecatalani@unitus.it.
Clara De PalmaUnit of Clinical Pharmacology, University Hospital "Luigi Sacco"-ASST Fatebenefratelli Sacco, 20157 Milano, Italy. clara.depalma@asst-fbf-sacco.it.
Cristiana PerrottaDepartment of Biomedical and Clinical Sciences "Luigi Sacco" (DIBIC), Università degli Studi di Milano, 20157 Milano, Italy. cristiana.perrotta@unimi.it.
Luis CucaDepartamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 111321, Colombia. lecucas@unal.edu.co.
Emilio ClementiDepartment of Biomedical and Clinical Sciences "Luigi Sacco" (DIBIC), Università degli Studi di Milano, 20157 Milano, Italy. emilio.clementi@unimi.it.
Davide CerviaDepartment for Innovation in Biological, Agro-food and Forest systems (DIBAF), Università degli Studi della Tuscia, 01100 Viterbo, Italy. d.cervia@unitus.it.
Universidad Nacional de Colombia · COUniversity of Milan · ITUniversità degli Studi della Tuscia · ITASST Fatebenefratelli Sacco · ITCancer Research UK Scotland Institute · GBUniversity of Applied and Environmental Sciences · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X-linked inhibitor of apoptosis protein (XIAP) is an emerging crucial therapeutic target in cancer. We report on the discovery and characterisation of small organic molecules from

Indexed as

apoptosiscaspase-independent cell deathcell deathhuman cancer cellsphytochemicalsPiper eriopodon, alkenylphenolssmall organic agentsXIAP antagonistsXIAP-BIR3 domain

Identifiers

PMID31505859
PMCPMC6770071
OpenAlexW2972680304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.