Evidence map›Paper›PMID 31505769›Full record

ArticleMarine drugs2019

Echinochrome A Promotes Ex Vivo Expansion of Peripheral Blood-Derived CD34

Ga-Bin Park, Min-Jung Kim, Elena A Vasileva, Natalia P Mishchenko, Sergey A Fedoreyev, Valentin A Stonik, Jin Han, Ho Sup Lee, Daejin Kim, Jee-Yeong Jeong

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ga-Bin ParkDepartment of Biochemistry, Cancer Research Institute, Kosin University College of Medicine, Busan 49267, Korea.
Min-Jung KimDepartment of Biochemistry, Cancer Research Institute, Kosin University College of Medicine, Busan 49267, Korea.
Elena A VasilevaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia. vasilieva_el_an@mail.ru.
Natalia P MishchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia. mischenkonp@mail.ru.ORCID 0000-0001-7616-574X
Sergey A FedoreyevG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia. fedoreev-s@mail.ru.
Valentin A StonikG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia. stonik@piboc.dvo.ru.
Jin HanNational Research Laboratory for Mitochondrial Signaling, Department of Physiology, Cardiovascular and Metabolic Disease Center, Inje University College of Medicine, Busan 47392, Korea. phyhanj@gmail.com.
Ho Sup LeeDepartment of Internal Medicine, Kosin University College of Medicine, Busan 49267, Korea. hs3667@hanmail.net.
Daejin KimDepartment of Anatomy, Inje University College of Medicine, Busan 47392, Korea. jyjeong@kosin.ac.kr.
Jee-Yeong JeongDepartment of Biochemistry, Cancer Research Institute, Kosin University College of Medicine, Busan 49267, Korea. kimdj@inje.ac.kr.ORCID 0000-0001-9482-4526
Kosin University · KRPacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences · RUInje University · KR

Funding

Ministry of Education and Science of the Russian Federation RFMEFI61317X0076National Research Foundation of Korea 2015M3A9B6073646; 2017M3A9G7072564; 2017K1A3A1A49070056
6 · The paper itself

Abstract

Intracellular reactive oxygen species (ROS) play an important role in the proliferation and differentiation of hematopoietic stem and progenitor cells (HSPCs). HSPCs are difficult to be expanded ex vivo while maintaining their stemness when they are exposed to oxidative damage after being released from the bone marrow. There have been efforts to overcome this limitation by using various cytokine cocktails and antioxidants. In this study, we investigated the effects of echinochrome A (Ech A)-a well-established and non-toxic antioxidant-on the ex vivo expansion of HSPCs by analyzing a CD34

Indexed as

AnthracenesAntigens, CD34AntioxidantsBlood CellsCells, CulturedDown-RegulationHematopoietic Stem CellsHumansImidazolesMitogen-Activated Protein KinasesNaphthoquinonesPhosphatidylinositol 3-KinasesPyridinesReactive Oxygen SpeciesSignal Transductionsrc-Family KinasesAnthracenesAntigens, CD34Antioxidantsechinochrome AImidazoleslyn protein-tyrosine kinaseMitogen-Activated Protein KinasesNaphthoquinonesPhosphatidylinositol 3-KinasespyrazolanthronePyridinesReactive Oxygen SpeciesSB 203580src-Family KinasesCD34+ cellsex vivo expansionhematopoietic stem and progenitor cellsLynp110δROSSrc

Identifiers

PMID31505769
PMCPMC6780187
OpenAlexW2972979440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.