ArticleBrain : a journal of neurology2019
Freezing of gait in Parkinson's disease reflects a sudden derangement of locomotor network dynamics.
Article in Brain : a journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76 citing papers in PubMed, 149 citations in OpenAlex.
- Nigral stimulation for freezing of gait: kinematic gait parameters inform optimization of stimulation frequency.Journal of neuroengineering and rehabilitation · 2025Trial
- Vertical locomotion improves horizontal locomotion: effects of climbing on gait and other mobility aspects in Parkinson's disease. A secondary analysis from a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2024Trial
- Natural Frequencies of Levodopa-Induced Dyskinesia in Parkinson's Disease.Annals of clinical and translational neurology · 2026Article
- Passive sensing of gait and medication-related fluctuations in Parkinson's disease.Journal of neuroengineering and rehabilitation · 2026Article
- Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Deep neurobehavioral phenotyping uncovers neural fingerprints of locomotor deficits in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Effectiveness of Music Therapy with Personalized Rhythmic Auditory Stimulation Plus Music-Contingent Gait Training in Patients with Parkinson's Disease: A Systematic Review.Neurology international · 2026Review
- Explainable SHAP- XGBoost with DAT and clinical data for freezing of gait detection in Parkinson disease.NPJ Parkinson's disease · 2026Article
- Temporal Features of Gamma Activity of Hyper-direct Pathway Regulated by Dopamine Receptors in the Dyskinetic Rat.Neuroscience bulletin · 2026Article
- Subthalamic Electrophysiological Mapping of Gait Initiation Dynamics and Freezing in Parkinson's Disease.Annals of neurology · 2025Article
- Neural signatures of turn-induced freezing of gait in Parkinson's disease: insights from phase-specific cortico-subthalamic dynamics.NPJ Parkinson's disease · 2025Article
- Regional-specific structural and functional changes of posterior cerebellar vermis across different stages of Parkinson's disease with gait dysfunction.NPJ Parkinson's disease · 2025Article
- Abnormal activity in the brainstem affects gait in a neuromusculoskeletal model.Journal of neuroengineering and rehabilitation · 2025Article
- Predicting Freezing of Gait in Parkinson's Disease: A Machine-Learning-Based Approach in ON and OFF Medication States.Journal of clinical medicine · 2025Article
- Could adaptive deep brain stimulation treat freezing of gait in Parkinson's disease?Journal of neurology · 2025Review
- Cortical networks of parkinsonian gait: a metabolic and functional connectivity study.Annals of clinical and translational neurology · 2024Article
- Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally-driven locomotion.Nature communications · 2024Article
- Unraveling the threads of stability: A review of the neurophysiology of postural control in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Program with last minute abstracts of the Padua Days on Muscle and Mobility Medicine, 27 February - 2 March, 2024 (2024Pdm3).European journal of translational myology · 2024Article
- Gait-related beta-gamma phase amplitude coupling in the subthalamic nucleus of parkinsonian patients.Scientific reports · 2024Article
16 more citing papers are in PubMed but not listed here.
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11 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Freezing of gait is a disabling symptom of Parkinson's disease that causes a paroxysmal inability to generate effective stepping. The underlying pathophysiology has recently migrated towards a dysfunctional supraspinal locomotor network, but the actual network derangements during ongoing gait freezing are unknown. We investigated the communication between the cortex and the subthalamic nucleus, two main nodes of the locomotor network, in seven freely-moving subjects with Parkinson's disease with a novel deep brain stimulation device, which allows on-demand recording of subthalamic neural activity from the chronically-implanted electrodes months after the surgical procedure. Multisite neurophysiological recordings during (effective) walking and ongoing gait freezing were combined with kinematic measurements and individual molecular brain imaging studies. Patients walked in a supervised environment closely resembling everyday life challenges. We found that during (effective) walking, the cortex and subthalamic nucleus were synchronized in a low frequency band (4-13 Hz). In contrast, gait freezing was characterized in every patient by low frequency cortical-subthalamic decoupling in the hemisphere with less striatal dopaminergic innervation. Of relevance, this decoupling was already evident at the transition from normal (effective) walking into gait freezing, was maintained during the freezing episode, and resolved with recovery of the effective walking pattern. This is the first evidence for a decoding of the networked processing of locomotion in Parkinson's disease and suggests that freezing of gait is a 'circuitopathy' related to a dysfunctional cortical-subcortical communication. A successful therapeutic approach for gait freezing in Parkinson's disease should aim at directly targeting derangements of neural network dynamics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.