ArticleJournal of neural engineering2019
Characterization of pallidocortical motor network in Parkinson's disease through complex network analysis.
Article in Journal of neural engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Altered brain white matter structural motor network in spinocerebellar ataxia type 3.Annals of clinical and translational neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveDeep brain stimulation (DBS) has been demonstrated by numerous clinical trials to be an advanced therapy for selected patients with Parkinson's disease (PD), while its maximal therapeutic effect is capped by the inadequate understanding of the precise neuronal mechanisms underlying PD. Recordings from multichannel electrodes placed in subcortical and cortical regions of the basal ganglia-thalamocortical (BGTC) motor network during DBS surgical procedures can provide rich physiologic information from accessible network nodes. However, most investigations focus on presumed spatio-spectral points of interest, neither fully utilizing the richness of spatial, spectral and temporal aspects of the multivariate signals nor making discoveries in the context of all possible candidates. In addition, aggregated network-level information has been missed out. APPROACH: We use complex network analysis to characterize functional network characteristics of the pallidocortical subcircuit of the BGTC motor network in PD at rest and with movement. The network matrix was constructed using distinct frequency bands at each anatomic recording site as virtual nodes and spectral connectivity (through phase-amplitude coupling and coherence) as network edges. MAIN
resultsWe confirm the critical roles of beta bands and provide additional evidence on their differential functional roles in the pallidocortical motor network. Moreover, significant changes (p < 0.05) in network functional segregation and integration between rest and movement conditions are revealed for the first time. More importantly, movement-dependent modulation of these network metrics are significantly correlated with hemibody unified PD rating scales (UPDRS), providing network-level perspectives of the pallidocortical motor network pertaining to PD symptoms (p < 0.05). SIGNIFICANCE: Findings in the present study provide network-level understanding of neuronal mechanisms in the pallidocortical motor network underlying PD. It is also highly plausible that the demonstrated approach can be applied in other important subcircuits towards a comprehensive understanding of the BGTC motor network.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.