Evidence map›Paper›PMID 31505241›Full record

ReviewNeuroscience letters2019

Updated mechanisms underlying sickle cell disease-associated pain.

Shibin Du, Corinna Lin, Yuan-Xiang Tao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. [Pain management in sickle cell disease].Schmerz (Berlin, Germany) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shibin DuDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Corinna LinRutgers Graduate School of Biomedical Sciences, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Yuan-Xiang TaoDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA; Rutgers Graduate School of Biomedical Sciences, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA. Electronic address: yuanxiang.tao@njms.rutgers.edu.

Funding

Role of dorsal root ganglion FTO, a RNA demethylase, in neuropathic painR01NS111553 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI TAO, YUAN-XIANG · 2019 to 2023
$2.5M
Dissection of a new spinal cord circuit in pain sensationR01NS094224 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUO, WENQIN · 2016 to 2020
$2.5M
Epigenetic regulation of neuropathic pain: Role of DRG histone methyltransferase G9aR01NS094664 · NINDS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI TAO, YUAN-XIANG · 2016 to 2020
$2.0M
NINDS NIH HHS R01 NS094224NINDS NIH HHS R01 NS094664NINDS NIH HHS R01 NS111553
6 · The paper itself

Abstract

Sickle cell disease (SCD) is one of the most common severe genetic diseases around the world. A majority of SCD patients experience intense pain, leading to hospitalization, and poor quality of life. Opioids form the bedrock of pain management, but their long-term use is associated with severe side effects including hyperalgesia, tolerance and addiction. Recently, excellent research has shown some new potential mechanisms that underlie SCD-associated pain. This review focused on how transient receptor potential vanilloid 1, endothelin-1/endothelin type A receptor, and cannabinoid receptors contributed to the pathophysiology of SCD-associated pain. Understanding these mechanisms may open a new avenue in managing SCD-associated pain and improving quality of life for SCD patients.

Indexed as

Anemia, Sickle CellHumansPainQuality of LifeReceptor, Endothelin AReceptors, CannabinoidTRPV Cation ChannelsReceptor, Endothelin AReceptors, CannabinoidTRPV1 protein, humanTRPV Cation ChannelsCannabinoid receptorsEndothelin-1Endothelin type A receptorPainSickle cell diseaseTRPV1

Identifiers

PMID31505241
PMCPMC6815235

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.