ReviewJournal of neuroendocrinology2020
Neurobehavioural complications of sleep deprivation: Shedding light on the emerging role of neuroactive steroids.
Review in Journal of neuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Corticosteroid-induced manic and/or psychotic symptoms: a systematic review.Frontiers in pharmacology · 2025Pooled it
- Association of Domain-Specific Physical Activity with Sleep Disorders in U.S. Adults: A Cross-Sectional Study Based on NHANES.Healthcare (Basel, Switzerland) · 2026Article
- Sleep deprivation impairs information processing via dysregulation of chloride homeostasis in the prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- How depression affects school social adaptation: the mediating role of sleep quality and the buffering effect of physical activity.Frontiers in sports and active living · 2025Article
- Exploring Astrocyte-Mediated Mechanisms in Sleep Disorders and Comorbidity.Biomedicines · 2023Review
- Gallic Acid Ameliorates Cognitive Impairment Caused by Sleep Deprivation through Antioxidant Effect.Experimental neurobiology · 2023Article
- Modeling resilience to sleep disruption to study resistance to Alzheimer's disease.Aging pathobiology and therapeutics · 2023Article
- X-linked ichthyosis: New insights into a multi-system disorder.Skin health and disease · 2022Review
- Allopregnanolone and depression and anxiety symptoms across the peripartum: an exploratory study.Archives of women's mental health · 2022Article
- Preoptic Area Modulation of Arousal in Natural and Drug Induced Unconscious States.Frontiers in neuroscience · 2021Review
- Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage.Frontiers in pharmacology · 2020Article
- Resilience to acute sleep deprivation is associated with attenuation of hippocampal mediated learning impairment.Aging pathobiology and therapeutics · 2020Article
- Effect of the anodal transcranial direct current electrical stimulation on cognition of medical residents with acute sleep deprivation.Sleep science (Sao Paulo, Brazil)Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Sleep deprivation (SD) is associated with a broad spectrum of cognitive and behavioural complications, including emotional lability and enhanced stress reactivity, as well as deficits in executive functions, decision making and impulse control. These impairments, which have profound negative consequences on the health and productivity of many individuals, reflect alterations of the prefrontal cortex (PFC) and its connectivity with subcortical regions. However, the molecular underpinnings of these alterations remain elusive. Our group and others have begun examining how the neurobehavioural outcomes of SD may be influenced by neuroactive steroids, a family of molecules deeply implicated in sleep regulation and the stress response. These studies have revealed that, similar to other stressors, acute SD leads to increased synthesis of the neurosteroid allopregnanolone in the PFC. Whereas this up-regulation is likely aimed at counterbalancing the detrimental impact of oxidative stress induced by SD, the increase in prefrontal allopregnanolone levels contributes to deficits in sensorimotor gating and impulse control, signalling a functional impairment of PFC. This scenario suggests that the synthesis of neuroactive steroids during acute SD may be enacted as a neuroprotective response in the PFC; however, such compensation may in turn set off neurobehavioural complications by interfering with the corticolimbic connections responsible for executive functions and emotional regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.