Evidence map›Paper›PMID 31505038›Full record

ArticleHepatology (Baltimore, Md.)2020

Monoacylglycerol Lipase Inhibition Protects From Liver Injury in Mouse Models of Sclerosing Cholangitis.

Matteo Tardelli, Francesca V Bruschi, Claudia D Fuchs, Thierry Claudel, Nicole Auer, Victoria Kunczer, Maximilian Baumgartner, Onne A H O Ronda, Henk Jan Verkade, Tatjana Stojakovic and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hepatology (Baltimore, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  5. MUW researcher of the month.Wiener klinische Wochenschrift · 2022
    Article
  6. [Acta pharmaceutica Sinica. B · 2022
    Article
  7. Article
  8. Circulating prostaglandin EClinical and experimental medicine · 2021
    Article
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Matteo TardelliHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Francesca V BruschiHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-5006-5473
Claudia D FuchsHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Thierry ClaudelHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Nicole AuerHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Victoria KunczerHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Maximilian BaumgartnerDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Onne A H O RondaCenter for Liver, Digestive and Metabolic Diseases, Departments of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Henk Jan VerkadeCenter for Liver, Digestive and Metabolic Diseases, Departments of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Tatjana StojakovicClinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz, Austria.
Hubert ScharnaglClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Aida HabibUniversité de Paris, Centre de Recherche sur l'Inflammation, INSERM, UMR1149, CNRS, ERL 8252, Paris, France.ORCID 0000-0001-6027-0043
Robert ZimmermannInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Sophie LotersztajnUniversité de Paris, Centre de Recherche sur l'Inflammation, INSERM, UMR1149, CNRS, ERL 8252, Paris, France.
Michael TraunerHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATCentre National de la Recherche Scientifique · FRUniversity Medical Center Groningen · NLMedical University of Graz · ATUniversity of Graz · AT

Funding

Austrian Science Fund FWF I2661
6 · The paper itself

Abstract

BACKGROUND AND

aimsMonoacylglycerol lipase (MGL) is the last enzymatic step in triglyceride degradation, hydrolyzing monoglycerides into glycerol and fatty acids (FAs) and converting 2-arachidonoylglycerol into arachidonic acid, thus providing ligands for nuclear receptors as key regulators of hepatic bile acid (BA)/lipid metabolism and inflammation. We aimed to explore the role of MGL in the development of cholestatic liver and bile duct injury in mouse models of sclerosing cholangitis, a disease so far lacking effective pharmacological therapy. APPROACH AND

resultsTo this aim we analyzed the effects of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) feeding to induce sclerosing cholangitis in wild-type (WT) and knockout (MGL

conclusionsCollectively, our study unravels MGL as a metabolic target, demonstrating that MGL inhibition may be considered as potential therapy for sclerosing cholangitis.

Indexed as

AnimalsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BBenzodioxolesBile Acids and SaltsCaco-2 CellsCholangitis, SclerosingCholestasisDisease Models, AnimalEnzyme InhibitorsFatty AcidsHumansLiver Cirrhosis, BiliaryMaleMice, Inbred C57BLMice, Knockout3,5-diethoxycarbonyl-1,4-dihydrocollidineATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BBenzodioxolesBile Acids and SaltsEnzyme InhibitorsFatty AcidsJZL 184Monoacylglycerol LipasesPiperidinesPyridines

Identifiers

PMID31505038
PMCPMC7317927
OpenAlexW2972797735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.