ArticleSchizophrenia bulletin2020
Effect of Risperidone Monotherapy on Dynamic Functional Connectivity of Insular Subdivisions in Treatment-Naive, First-Episode Schizophrenia.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity.Brain structure & function · 2026Article
- Observational
- Functional Inertia Index of Memory-Retaining Brain Dynamics: A Measure of Large-Scale Brain Adaptability.bioRxiv : the preprint server for biology · 2025Article
- Neuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade.Schizophrenia bulletin · 2025Review
- Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions.Schizophrenia bulletin · 2025Review
- Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis.Schizophrenia research · 2025Article
- Immunomodulatory treatment may change functional and structural brain imaging in severe mental disorders.Brain, behavior, & immunity - health · 2024Article
- Functional Connectivity Between Auditory and Medial Temporal Lobe Networks in Antipsychotic-Naïve Patients With First-Episode Schizophrenia Predicts the Effects of Dopamine Antagonism on Auditory Verbal Hallucinations.Biological psychiatry global open science · 2024Article
- Altered dynamic functional connectivity of insular subdivisions among male cigarette smokers.Frontiers in psychiatry · 2024Article
- The Duration of Chronic Pain Can Affect Brain Functional Changes of the Pain Matrix in Patients with Chronic Back Pain: A Resting-State fMRI Study.Journal of pain research · 2024Article
- Effects of long-term antipsychotic medication on brain instability in first-episode schizophrenia patients: a resting-state fMRI study.Frontiers in pharmacology · 2024Article
- Meta-Analysis of the Efficacy of Risperidone Treatment in Patients with First-Episode Schizophrenia.Noro psikiyatri arsivi · 2024Article
- Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?Reports (MDPI) · 2023Review
- Abnormal characterization of dynamic functional connectivity in Alzheimer's disease.Neural regeneration research · 2022Article
- Time-varying dynamic network model for dynamic resting state functional connectivity in fMRI and MEG imaging.NeuroImage · 2022Article
- Deep rTMS of the insula and prefrontal cortex in smokers with schizophrenia: Proof-of-concept study.Schizophrenia (Heidelberg, Germany) · 2022Article
- Differential functional connectivity of insular subdivisions in de novo Parkinson's disease with mild cognitive impairment.Brain imaging and behavior · 2022Article
- Treatment Effect of Long-Term Antipsychotics on Default-Mode Network Dysfunction in Drug-Naïve Patients With First-Episode Schizophrenia: A Longitudinal Study.Frontiers in pharmacology · 2022Article
- Frequency-specific altered global signal topography in drug-naïve first-episode patients with adolescent-onset schizophrenia.Brain imaging and behavior · 2021Article
- Dynamic functional connectivity and its anatomical substrate reveal treatment outcome in first-episode drug-naïve schizophrenia.Translational psychiatry · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
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Abstract
objectiveThe insula consists of functionally diverse subdivisions, and each division plays different roles in schizophrenia neuropathology. The current study aimed to investigate the abnormal patterns of dynamic functional connectivity (dFC) of insular subdivisions in schizophrenia and the effect of antipsychotics on these connections.
methodsLongitudinal study of the dFC of insular subdivisions was conducted in 42 treatment-naive first-episode patients with schizophrenia at baseline and after 8 weeks of risperidone treatment based on resting-state functional magnetic resonance image (fMRI).
resultsAt baseline, patients showed decreased dFC variance (less variable) between the insular subdivisions and the precuneus, supplementary motor area and temporal cortex, as well as increased dFC variance (more variable) between the insular subdivisions and parietal cortex, compared with healthy controls. After treatment, the dFC variance of the abnormal connections were normalized, which was accompanied by a significant improvement in positive symptoms.
conclusionsOur findings highlighted the abnormal patterns of fluctuating connectivity of insular subdivision circuits in schizophrenia and suggested that these abnormalities may be modified after antipsychotic treatment.
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