Evidence map›Paper›PMID 31504882›Full record

Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2020

Withdrawal Symptoms From E-Cigarette Abstinence Among Adult Never-Smokers: A Pilot Experimental Study.

John R Hughes, Erica N Peters, Peter W Callas, Catherine Peasley-Miklus, Emmanuel Oga, Jean-Francois Etter, Nicholas Morley

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02825459 (Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02825459 nacompletednot on this map

Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?

TypeinterventionalSponsorUniversity of VermontRan2016 to 2018Enrolled147ConditionsSubstance Withdrawal SyndromeArmsAbstinence from e-cigarettes
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Unique, long-term effects of nicotine on adolescent brain.Pharmacology, biochemistry, and behavior · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

John R HughesDepartments of Psychiatry and Psychological Science, Vermont Center for Behavior and Health, University of Vermont, Burlington, VT.
Erica N PetersBattelle Public Health Center for Tobacco Research, Baltimore, MD.
Peter W CallasMedical Biostatistics, University of Vermont, Burlington, VT.
Catherine Peasley-MiklusDepartments of Psychiatry and Psychological Science, Vermont Center for Behavior and Health, University of Vermont, Burlington, VT.
Emmanuel OgaBattelle Public Health Center for Tobacco Research, Baltimore, MD.
Jean-Francois EtterInstitute of Global Health, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Nicholas MorleyDepartments of Psychiatry and Psychological Science, Vermont Center for Behavior and Health, University of Vermont, Burlington, VT.

Funding

Does Abstinence from E-cigarettes Produce Withdrawal Symptoms?R01CA192940 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUGHES, JOHN R · 2015 to 2017
$1.9M
NCI NIH HHS R01 CA192940
6 · The paper itself

Abstract

introductionUse of e-cigarettes among never-smokers has substantially increased; yet there are few descriptions of the consequences of such use. We assessed whether adult never-smokers can have withdrawal from cessation of e-cigarettes.

methodsIn an un-blinded pre-post clinical trial, 30 never-smoker daily e-cigarette users used their own nicotine-containing e-cigarette for 7 days followed by 6 days of biologically confirmed abstinence. Participants monitored symptoms of nicotine withdrawal nightly via an Interactive Voice Response system. They attended three lab visits/week to provide expired carbon monoxide and urine samples to determine compliance.

findingsAbstinence increased all the DSM5 symptoms of tobacco withdrawal and this occurred in the majority of participants. The increase in severity of withdrawal was small and rarely impaired functioning.

conclusionsOur finding suggests that withdrawal symptoms can occur in never-smokers who stop e-cigarettes abruptly. However, the severity of withdrawal appears to be small and may not be of clinical or regulatory significance. Although our sample size was small and thus replication tests of our results are indicated, it may be prudent to warn never-smokers that withdrawal symptoms may occur. IMPLICATIONS: This study indicates that withdrawal symptoms can occur in never-smokers who are daily e-cigarette users. However, the severity of withdrawal from e-cigarette abstinence in never-smokers appears to be small and may not be of clinical or regulatory significance. Given our small sample size, replication of our results is warranted. Nevertheless, it might be prudent to warn never-smokers of addiction to e-cigarettes.Clinical Trial Registration = NCT02825459.

Indexed as

Behavior, AddictiveHealth BehaviorAdultCarbon MonoxideElectronic Nicotine Delivery SystemsFemaleHumansMalePilot ProjectsSmokersSmoking CessationSubstance Withdrawal SyndromeUnited StatesYoung AdultCarbon Monoxide

Identifiers

PMID31504882
PMCPMC7171287

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.