ArticleMolecular biology and evolution2019
Butterfly Mimicry Polymorphisms Highlight Phylogenetic Limits of Gene Reuse in the Evolution of Diverse Adaptations.
Article in Molecular biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 42 citations in OpenAlex.
- Whole-genome analyses illuminate demographic history and lineage differentiation of polymorphic swallowtail butterfly Papilio bootes.BMC genomics · 2026Article
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- The genetics and evolution of moth melanism in the absence of strong natural selection.National science review · 2026Article
- A microRNA is the effector gene of a classic evolutionary hotspot locus.Science (New York, N.Y.) · 2024Article
- Hidden in plain sight: (Re)definition of a key lepidopteran color patterning gene.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2024Article
- A long noncoding RNA at theProceedings of the National Academy of Sciences of the United States of America · 2024Article
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- A micro-RNA is the effector gene of a classic evolutionary hotspot locus.bioRxiv : the preprint server for biology · 2024Article
- Transposable Element Insertions Are Associated with Batesian Mimicry in the Pantropical Butterfly Hypolimnas misippus.Molecular biology and evolution · 2024Article
- Butterfly mimicry rings run in circles.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Association mapping of colour variation in a butterfly provides evidence that a supergene locks together a cluster of adaptive loci.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Genomic architecture and functional unit of mimicry supergene in female limited Batesian mimicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- High-quality reference genomes of swallowtail butterflies provide insights into their coloration evolution.Zoological research · 2022Article
- A large deletion at the cortex locus eliminates butterfly wing patterning.G3 (Bethesda, Md.) · 2022Article
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- Evolution of sexual development and sexual dimorphism in insects.Current opinion in genetics & development · 2021Review
- Heliconius butterflies: a window into the evolution and development of diversity.Current opinion in genetics & development · 2021Review
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- De novo genome assemblies of butterflies.GigaScience · 2021Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Some genes have repeatedly been found to control diverse adaptations in a wide variety of organisms. Such gene reuse reveals not only the diversity of phenotypes these unique genes control but also the composition of developmental gene networks and the genetic routes available to and taken by organisms during adaptation. However, the causes of gene reuse remain unclear. A small number of large-effect Mendelian loci control a huge diversity of mimetic butterfly wing color patterns, but reasons for their reuse are difficult to identify because the genetic basis of mimicry has primarily been studied in two systems with correlated factors: female-limited Batesian mimicry in Papilio swallowtails (Papilionidae) and non-sex-limited Müllerian mimicry in Heliconius longwings (Nymphalidae). Here, we break the correlation between phylogenetic relationship and sex-limited mimicry by identifying loci controlling female-limited mimicry polymorphism Hypolimnas misippus (Nymphalidae) and non-sex-limited mimicry polymorphism in Papilio clytia (Papilionidae). The Papilio clytia polymorphism is controlled by the genome region containing the gene cortex, the classic P supergene in Heliconius numata, and loci controlling color pattern variation across Lepidoptera. In contrast, female-limited mimicry polymorphism in Hypolimnas misippus is associated with a locus not previously implicated in color patterning. Thus, although many species repeatedly converged on cortex and its neighboring genes over 120 My of evolution of diverse color patterns, female-limited mimicry polymorphisms each evolved using a different gene. Our results support conclusions that gene reuse occurs mainly within ∼10 My and highlight the puzzling diversity of genes controlling seemingly complex female-limited mimicry polymorphisms.
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