ArticleThe Journal of nutrition2020
Obesity and Insulin Resistance Are Inversely Associated with Serum and Adipose Tissue Carotenoid Concentrations in Adults.
Article in The Journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 73 citations in OpenAlex.
- Oxidative Stress as a Pathophysiological Core of Obesity: Preclinical Evidence for Antioxidant-Based Therapy Strategies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Genetic Determinants of Interindividual Differences in Provitamin A Carotenoid Concentrations in Human Adipose Tissue.Molecular nutrition & food research · 2026Observational
- Validation of Noninvasive Cutaneous Carotenoid Measurements as Nutritional Biomarker Across Body Composition Groups.Food science & nutrition · 2026Article
- Blood Serum From Obese Women Raises ROS Production by Neural Stem Cells.Developmental neurobiology · 2026Article
- Dietary intake of individual and total carotenoids in relation to overweight and obesity: findings from the PERSIAN cohort study.Nutrition & metabolism · 2026Review
- Bioactive Lipophilic Antioxidants (Carotenoids, Tocols, Retinol, and Coenzyme QAntioxidants (Basel, Switzerland) · 2025Article
- Pigment Extracts ofInternational journal of molecular sciences · 2025Article
- Serum and Skin Carotenoid Levels in Older Adults with and Without Metabolic Syndrome: A Cross-Sectional Study.Nutrients · 2025Article
- Diet Therapy and Probiotics to Improve Sleep Apnea Risk and Quality of Life in Older Adults (>60 Years) with Metabolic Syndrome: A Study from Romania.Geriatrics (Basel, Switzerland) · 2025Article
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- Protective effect of serum carotenoids on mortality among metabolic syndrome patients: attenuated by lipid-lowering drugs.Nutrition journal · 2025Article
- The gut-liver axis links the associations between serum carotenoids and non-alcoholic fatty liver in a 7.8-year prospective study.Hepatobiliary surgery and nutrition · 2025Article
- The Relationship Between Lycopene and Metabolic Diseases.Nutrients · 2024Review
- Effects of Zeaxanthin on the Insulin Resistance and Gut Microbiota of High-Fat-Diet-Induced Obese Mice.Foods (Basel, Switzerland) · 2024Article
- Preliminary Assessment of the Protective and Antitumor Effects of Several Phytoene-Containing Bacterial and Microalgal Extracts in Colorectal Cancer.Molecules (Basel, Switzerland) · 2024Article
- Associations between dietary iron intake from different sources and non-alcoholic fatty liver disease in adults.Asia Pacific journal of clinical nutrition · 2024Article
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- Skin Carotenoid Levels Are Associated with Demographic Factors, Body Size, and Fruit and Vegetable Intake in the Japanese Population.Nutrients · 2024Article
- Increasing adipocyte number and reducing adipocyte size: the role of retinoids in adipose tissue development and metabolism.Critical reviews in food science and nutrition · 2024Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow tissue concentrations of carotenoids have been suggested to contribute to insulin resistance in obesity.
objectivesThe objectives of the study were to 1) evaluate the relations of adipose tissue and serum carotenoids with body fat, abdominal fat distribution, muscle, adipose tissue and liver insulin resistance, and dietary intake; 2) evaluate the relations and distributions of carotenoids detected in adipose tissue and serum; and 3) compare serum carotenoids and retinol concentrations in subjects with and without obesity.
methodsPost hoc analysis of serum and adipose tissue carotenoids in individuals [n = 80; 31 men, 49 women; age (mean ± SEM): 51.4 ± 1.1 y] who participated in 2 separate studies conducted at the Clinical Research Facility at the Garvan Institute of Medical Research (Sydney) between 2008 and 2013. Retinol, α-carotene, β-carotene, ζ-carotene, lutein, lycopene, phytoene, and phytofluene were measured using HPLC. Body composition was measured by dual-energy X-ray absorptiometry. Insulin resistance was measured by 2-step hyperinsulinemic-euglycemic clamps with deuterated glucose (n = 64), and subcutaneous and visceral abdominal volume and liver and pancreatic fat by MRI (n = 60). Periumbilical subcutaneous fat biopsy was performed and carotenoids and retinol measured in the tissue (n = 16).
resultsWe found that ζ-carotene, phytoene, and phytofluene were stored in considerable amounts in adipose tissue (25% of adipose tissue carotenoids). Carotenoid concentrations in adipose tissue and serum correlated significantly, but they followed different distributions: ζ-carotene was 3-fold higher in adipose tissue compared with serum, while lutein and lycopene made up 20% and 21% of serum carotenoids compared with 2% and 12% of adipose tissue carotenoids, respectively. Liver (P ≤ 0.028) and adipose tissue (P = 0.023), but not muscle (P ≥ 0.16), insulin resistance correlated inversely with many of the serum carotenoids.
conclusionsMultiple serum and adipose tissue carotenoids are associated with favorable metabolic traits, including insulin sensitivity in liver and adipose tissue in humans.
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