Evidence map›Paper›PMID 31504712›Full record

ArticleJournal of travel medicine2019

'More than devastating'-patient experiences and neurological sequelae of Japanese encephalitis§.

Lance Turtle, Ava Easton, Sylviane Defres, Mark Ellul, Begona Bovill, Jim Hoyle, Agam Jung, Penny Lewthwaite, Tom Solomon

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Journal of travel medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Flaviviruses-Induced Neurological Sequelae.Pathogens (Basel, Switzerland) · 2024
    Review
  10. Article
  11. In Vitro Antiviral Activity ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  12. Review
  13. Japanese Encephalitis among Adults: A Review.The American journal of tropical medicine and hygiene · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Lance TurtleInstitute of Infection and Global Health, University of Liverpool, 8 West Derby Street, Liverpool, L69 7BE, UK.
Ava EastonInstitute of Infection and Global Health, University of Liverpool, 8 West Derby Street, Liverpool, L69 7BE, UK.
Sylviane DefresInstitute of Infection and Global Health, University of Liverpool, 8 West Derby Street, Liverpool, L69 7BE, UK.
Mark EllulInstitute of Infection and Global Health, University of Liverpool, 8 West Derby Street, Liverpool, L69 7BE, UK.
Begona BovillTropical and Infectious Diseases, North Bristol NHS Trust, Bristol, Southmead Road, Westbury-on-Trym, BS10 5NB, UK.
Jim HoyleNeuro-Intensive Care Unit, Royal Hallamshire Hospital, Sheffield, Glossop Rd, S10 2JF, UK.
Agam JungLeeds General Infirmary, Leeds, LS1 3EX, UK.
Penny LewthwaiteSt James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, Beckett Street, LS9 7TF, UK.
Tom SolomonInstitute of Infection and Global Health, University of Liverpool, 8 West Derby Street, Liverpool, L69 7BE, UK.
University of Liverpool · GBLeeds General Infirmary · GBLeeds Teaching Hospitals NHS Trust · GBNorth Bristol NHS Trust · GBRoyal Hallamshire Hospital · GB

Funding

Department of Health EME/12/205/28Department of Health IS-HPU-1112-10117Department of Health RP-PG-0108-10048Medical Research Council G116/194Medical Research Council MC_PC_15096Wellcome Trust 205228/Z/16/Z
6 · The paper itself

Abstract

backgroundJapanese encephalitis (JE), caused by the mosquito-borne JE virus, is a vaccine-preventable disease endemic to much of Asia. Travellers from non-endemic areas are susceptible if they travel to a JE endemic area. Although the risk to travellers of JE is low, the consequences may be severe.

methodsHere, we describe three cases of JE in British travellers occurring in 2014-15. In addition, we report, through interviews with survivors and their families, personal experiences of life after JE.

resultsThree cases of JE were diagnosed in British travellers in 2014/15. One was acquired in Thailand, one in China and one in either Thailand, Laos or Cambodia. All three patients suffered severe, life-threatening illnesses, all were admitted to intensive care units and required medical evacuation back to the UK. One patient suffered a cardiac arrest during the acute stage but made a good recovery. The other two patients remain significantly paralysed and ventilator dependent. All three cases had clear indications for vaccination, and all have been left with life-changing neurological sequelae.

conclusionsTravel health providers should be aware of the severity of JE, as well as the risk, allowing travellers to make fully informed decisions on JE vaccination.

Indexed as

TravelAdultEncephalitis, JapaneseEncephalitis Virus, JapaneseFemaleHumansJapanese Encephalitis VaccinesMagnetic Resonance ImagingMaleRetrospective StudiesSeverity of Illness IndexYoung AdultJapanese Encephalitis VaccinesJapanese encephalitisJapanese encephalitis vaccineJEJE vaccineJE virusTravellerTravel medicine

Identifiers

PMID31504712
PMCPMC6792067
OpenAlexW2970412118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.