ReviewJournal of the National Cancer Institute2020
Potential Effect of Immunotherapy Agents on Cognitive Function in Cancer Patients.
Review in Journal of the National Cancer Institute, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- 6th and 7th International consensus guidelines for the management of advanced breast cancer (ABC guidelines 6 and 7).Breast (Edinburgh, Scotland) · 2024Guideline
- Cognitive impairment following breast cancer treatments: an umbrella review.The oncologist · 2024Pooled it
- Insomnia in patients treated with checkpoint inhibitors for cancer: A meta-analysis.Frontiers in oncology · 2022Pooled it
- Evaluating the heterogeneity of hippocampal avoidant whole brain radiotherapy treatment effect: A secondary analysis of NRG CC001.Neuro-oncology · 2024Trial
- Identifying pre-treatment risk factors for cancer-related cognitive decline in patients with breast cancer.Breast (Edinburgh, Scotland) · 2026Article
- Rationale and study protocol for a randomized controlled MIND diet feeding trial for breast cancer-related cognitive impairment.Contemporary clinical trials · 2026Article
- Longitudinal trajectories of cancer-related cognitive impairment and influential factors among patients with lung cancer.Comprehensive psychoneuroendocrinology · 2026Article
- Article
- Unveiling Cognitive Impairment in Older Adults with Cancer on Systemic Anticancer Therapy: A Comprehensive Review.Drugs & aging · 2025Review
- Changes of perioperative cognitive function and its effect on quality of life in laryngeal cancer.Perioperative medicine (London, England) · 2025Article
- Screening for cognitive impairment in routine clinical oncology practice: a pilot study using patient-reported outcome measures and online cognitive testing in melanoma and breast cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Immune checkpoint inhibitors and cancer-related cognitive decline: a propensity score matched analysis in active chemotherapy patients.Frontiers in immunology · 2025Article
- Neurological complications in oncology and their monitoring and management in clinical practice: a narrative review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Review
- Individualized trajectories in postradiotherapy neurocognitive functioning of patients with brain metastases.Neuro-oncology practice · 2024Article
- Characterizing the Physical and Psychological Experiences of Newly Diagnosed Pancreatic Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- "I couldn't connect the wires in my brain." Young adult cancer survivors' experience with cognitive functioning.Psycho-oncology · 2024Article
- Expanded taxonomies of human memory.Frontiers in cognition · 2024Review
- Changes in physical activity, sedentary behavior, and self-reported cognitive function in cancer survivors before and during the COVID-19 pandemic: A cross-sectional study.Journal of sport and health science · 2023Article
- Whole-brain radiotherapy associated with structural changes resembling aging as determined by anatomic surface-based deep learning.Neuro-oncology · 2023Article
- Cognitive adverse events in patients with lung cancer treated with checkpoint inhibitor monotherapy: a propensity score-matched analysis.EClinicalMedicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A paradigm shift is occurring in cancer therapy, where instead of targeting tumor cells, immunotherapy agents (IA) target the immune system to overcome cancer tolerance and to stimulate an antitumor immune response. IA using immune checkpoint inhibitors (CPI) or chimeric antigen receptor T-cells have emerged as the most encouraging approaches to treat cancer patients. CPI are reported to induce moderate-to-severe neurologic immune-related adverse events in less than 1% of patients, whereas chimeric antigen receptor T-cell therapy is associated with frequent neurological toxicities that can be severe or even fatal. Cognitive difficulties have been described following chemotherapy and targeted therapy, but not specifically explored in patients receiving IA. The aim of this review is to establish a picture of the first published studies suggesting some biological and physiopathological effects of IA on cognitive functions among cancer patients. The first results originate from a preclinical study evaluating the role of CPI associated with peripheral radiation on cognitive dysfunction and the recent discovery of the central nervous lymphatic system allowing leukocytes to penetrate the central nervous system. Evaluating possible side effects of IA on cognitive function will be an important challenge for future clinical trials and for better understanding the underlying mechanisms through preclinical animal models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.