Evidence map›Paper›PMID 31504550›Full record

SynthesisHuman molecular genetics2019

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.

Jonathan P Bradfield, Suzanne Vogelezang, Janine F Felix, Alessandra Chesi, Øyvind Helgeland, Momoko Horikoshi, Ville Karhunen, Estelle Lowry, Diana L Cousminer, Tarunveer S Ahluwalia and 90 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human molecular genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Review
  9. Management of Childhood Obesity.International journal of molecular sciences · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Genetics of Common Obesity in Children and Adolescents.Annals of the New York Academy of Sciences · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

100 authors.

Jonathan P BradfieldCenter for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Suzanne VogelezangThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Alessandra ChesiDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Øyvind HelgelandKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Momoko HorikoshiWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Ville KarhunenDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, W2 1PG, UK.
Estelle LowryCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, PO Box 8000, FI-90014 Oulun yliopisto, Finland.
Diana L CousminerDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tarunveer S AhluwaliaCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital 2820, University of Copenhagen, Copenhagen, Denmark.
Elisabeth ThieringHelmholtz Zentrum München-German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany.
Eileen Tai-Hui BohSaw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.
Mohammad H ZafarmandDepartment of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, The Netherlands.
Natalia Vilor-TejedorDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Carol A WangSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle.
Raimo JoroInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.
Zhanghua ChenDepartment of Preventive Medicine, University of Southern California, Los Angeles, California, USA.
William J GaudermanDepartment of Preventive Medicine, University of Southern California, Los Angeles, California, USA.
Niina PitkänenDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland.
Esteban J ParraDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada.
Lindsay Fernandez-RhodesDepartment of Biobehavioral Health, Pennsylvania State University.
Akram AlyassDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Claire MonnereauThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
John A CurtinDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust.
Christian T HaveNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Shana E McCormackDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mette HollenstedNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Christine Frithioff-BøjsøeNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Adan Valladares-SalgadoUnidad de Investigacion Medica en Bioquımica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Jesus Peralta-RomeroUnidad de Investigacion Medica en Bioquımica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Yik-Ying TeoSaw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.
Marie StandlHelmholtz Zentrum München-German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany.
Jaakko T LeinonenInstitute for Molecular Medicine Finland, FIMM, University of Helsinki, Finland.
Jens-Christian HolmNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Triinu PetersDepartment of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Germany.
Jesus VioqueCIBER de Epidemiología y Salud Pública, Madrid, Spain.
Martine VrijheidISGlobal, Institute for Global Health, Barcelona, Spain.
Angela SimpsonDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust.
Adnan CustovicDepartment of Paediatrics, Imperial College London, UK.
Marc VaudelKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Mickaël CanouilCNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, University of Lille, Lille, France.
Virpi LindiUniversity of Eastern Finland Library, Kuopio, Finland.
Mustafa AtalayInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland.
Barbera D C van SchaikDepartment of Clinical Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, The Netherlands.
Robert I BerkowitzDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Shelley A ColeTexas Biomedical Research Institute, San Antonio, TX.
V Saroja VorugantiDepartment of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill.
Yujie WangDepartment of Epidemiology, University of North Carolina at Chapel Hill.
Heather M HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill.
Anthony G ComuzzieThe Obesity Society.
Nancy F ButteDepartment of Pediatrics, Baylor College of Medicine.
Anne E JusticeDepartment of Epidemiology, University of North Carolina at Chapel Hill.
Sheila GahaganCenter for Community Health, Department of Pediatrics, University of California at San Diego.
Estela BlancoCenter for Community Health, Department of Pediatrics, University of California at San Diego.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Timo A LakkaInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.
Johannes HebebrandDepartment of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Germany.
Amélie BonnefondCNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, University of Lille, Lille, France.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Philippe FroguelCNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, University of Lille, Lille, France.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Miguel CruzUnidad de Investigacion Medica en Bioquımica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Sayuko KobesPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes Digestive and Kidney Diseases, NIH, USA.
Robert L HansonPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes Digestive and Kidney Diseases, NIH, USA.
Babette S ZemelDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Anke HinneyDepartment of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Germany.
Koon K TeoDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
David MeyreDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill.
Frank D GillilandDepartment of Preventive Medicine, University of Southern California, Los Angeles, California, USA.
Hans BisgaardCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital 2820, University of Copenhagen, Copenhagen, Denmark.
Mariona BustamanteISGlobal, Institute for Global Health, Barcelona, Spain.
Klaus BonnelykkeCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital 2820, University of Copenhagen, Copenhagen, Denmark.
Craig E PennellSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle.
Fernando RivadeneiraThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
André G UitterlindenDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Leslie J BaierPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes Digestive and Kidney Diseases, NIH, USA.
Tanja G M VrijkotteDepartment of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, The Netherlands.
Joachim HeinrichHelmholtz Zentrum München-German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany.
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Seang-Mei SawSaw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Johan ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Elisabeth WidénInstitute for Molecular Medicine Finland, FIMM, University of Helsinki, Finland.
Mark I McCarthyWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Pål R NjølstadKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Christine PowerPopulation, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Elina HyppönenPopulation, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Sylvain SebertCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, PO Box 8000, FI-90014 Oulun yliopisto, Finland.
Christopher D BrownDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Marjo-Riitta JärvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, W2 1PG, UK.
Nicholas J TimpsonMedical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.
Stefan JohanssonKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Vincent W V JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Early Growth Genetics Consortium
S F A Grant

Funding

Type 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8M
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Urban Air Pollution and Children's Respiratory HealthP01ES011627 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAUDERMAN, WILLIAM JAMES · 2002 to 2011
$30.2M
Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul Marjoram · 2016 to 2026
$25.5M
USC Tobacco Center of Regulatory Science (TCORS) for Vulnerable PopulationsP50CA180905 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PENTZ, MARY ANN, SAMET, JONATHAN M · 2013 to 2017
$20.1M
POPULATION STUDIEST32HD007168 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELIZABETH A FRANKENBERG · 1985 to 2026
$13.8M
Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Genome Wide Association Study for Childhood ObesityR01HD056465 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2008 to 2024
$9.5M
The EVE Asthma Genetics Consortium: Building Upon GWASRC2HL101651 · NHLBI · UNIVERSITY OF CHICAGO · PI NICOLAE, DAN LIVIU, OBER, CAROLE · 2009 to 2010
$7.4M
Medical Research Council G0601361Medical Research Council G1001799Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_12013/3Medical Research Council MR/K002449/1Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2NCI NIH HHS P01 CA196569NCI NIH HHS P50 CA180905NCRR NIH HHS C06 RR013556NCRR NIH HHS C06 RR017515NHLBI NIH HHS K99 HL130580NHLBI NIH HHS R01 HL061768NHLBI NIH HHS R01 HL076647NHLBI NIH HHS R01 HL087680NHLBI NIH HHS RC2 HL101651NHLBI NIH HHS T32 HL007055NICHD NIH HHS K99 HD099330NICHD NIH HHS P2C HD050924NICHD NIH HHS R01 HD056465NICHD NIH HHS T32 HD007168NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK080457NIDDK NIH HHS U01 DK062418NIEHS NIH HHS N01 ES075558NIEHS NIH HHS P01 ES009581NIEHS NIH HHS P01 ES011627NIEHS NIH HHS P01 ES022845NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES016535NIEHS NIH HHS R01 ES021801NIEHS NIH HHS R01 ES023262NIEHS NIH HHS R03 ES014046NINDS NIH HHS U01 NS047537Wellcome Trust 202802/Z/16/Z
6 · The paper itself

Abstract

Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of 30 studies consisting of up to 13 005 cases (≥95th percentile of body mass index (BMI) achieved 2-18 years old) and 15 599 controls (consistently <50th percentile of BMI) of European, African, North/South American and East Asian ancestry. Suggestive loci were taken forward for replication in a sample of 1888 cases and 4689 controls from seven cohorts of European and North/South American ancestry. In addition to observing 18 previously implicated BMI or obesity loci, for both early and late onset, we uncovered one completely novel locus in this trans-ancestral analysis (nearest gene, METTL15). The variant was nominally associated with only the European subgroup analysis but had a consistent direction of effect in other ethnicities. We then utilized trans-ancestral Bayesian analysis to narrow down the location of the probable causal variant at each genome-wide significant signal. Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to fewer than 10 single nucleotide polymorphisms (SNPs) (FAIM2, GNPDA2, MC4R and SEC16B loci). In conclusion, an ethnically diverse setting has enabled us to both identify an additional pediatric obesity locus and further fine-map existing loci.

Indexed as

Polymorphism, Single NucleotideBayes TheoremCase-Control StudiesChildChromosome MappingFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePediatric ObesityWilms Tumor

Identifiers

PMID31504550
PMCPMC6859434

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.