Evidence map›Paper›PMID 31504540›Full record

ArticleInflammatory bowel diseases2020

Assessing Small Bowel Stricturing and Morphology in Crohn's Disease Using Semi-automated Image Analysis.

Ryan W Stidham, Binu Enchakalody, Akbar K Waljee, Peter D R Higgins, Stewart C Wang, Grace L Su, Ashish P Wasnik, Mahmoud Al-Hawary

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Inflammatory bowel diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 66 citations in OpenAlex.

  1. Trial
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  4. Artificial intelligence in the management of inflammatory bowel disease: What's next?World journal of gastrointestinal pharmacology and therapeutics · 2026
    Review
  5. Article
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  8. Artificial intelligence in inflammatory bowel disease.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025
    Review
  9. How Artificial Intelligence Will Transform Clinical Care, Research, and Trials for Inflammatory Bowel Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Ryan W StidhamDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
Binu EnchakalodyMorphomic Analysis Program, University of Michigan, Ann Arbor, MI, USA.
Akbar K WaljeeDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
Peter D R HigginsDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
Stewart C WangMorphomic Analysis Program, University of Michigan, Ann Arbor, MI, USA.
Grace L SuDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
Ashish P WasnikMorphomic Analysis Program, University of Michigan, Ann Arbor, MI, USA.
Mahmoud Al-HawaryDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USMorpho (United States) · USAnn Arbor VA Medical Center · USVA Center for Clinical Management Research · US

Funding

Improving Prediction of Medical Responsiveness and Clinical Outcomes in Crohn's DiseaseK23DK101687 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STIDHAM, RYAN WILLIAM · 2015 to 2019
$945k
NIDDK NIH HHS K23 DK101687
6 · The paper itself

Abstract

backgroundEvaluating structural damage using imaging is essential for the evaluation of small intestinal Crohn's disease (CD), but it is limited by potential interobserver variation. We compared the agreement of enterography-based bowel damage measurements collected by experienced radiologists and a semi-automated image analysis system.

methodsPatients with small bowel CD undergoing a CT-enterography (CTE) between 2011 and 2017 in a tertiary care setting were retrospectively reviewed. CT-enterography studies were reviewed by 2 experienced radiologists and separately underwent automated computer image analysis using bowel measurement software. Measurements included maximum bowel wall thickness (BWT-max), maximum bowel dilation (DIL-max), minimum lumen diameter (LUM-min), and the presence of a stricture. Measurement correlation coefficients and paired t tests were used to compare individual operator measurements. Multivariate regression was used to model identification of strictures using semi-automated measures.

resultsIn 138 studies, the correlation between radiologists and semi-automated measures were similar for BWT-max (r = 0.724, 0.702), DIL-max (r = 0.812, 0.748), and LUM-min (r = 0.428, 0.381), respectively. Mean absolute measurement difference between semi-automated and radiologist measures were no different from the mean difference between paired radiologists for BWT-max (1.26 mm vs 1.12 mm, P = 0.857), DIL-max (2.78 mm vs 2.67 mm, P = 0.557), and LUM-min (0.54 mm vs 0.41 mm, P = 0.596). Finally, models of radiologist-defined intestinal strictures using automatically acquired measurements had an accuracy of 87.6%.

conclusionStructural bowel damage measurements collected by semi-automated approaches are comparable to those of experienced radiologists. Radiomic measures of CD will become an important new data source powering clinical decision-making, patient-phenotyping, and assisting radiologists in reporting objective measures of disease status.

Indexed as

AdultCrohn DiseaseFemaleHumansImage Processing, Computer-AssistedIntestinal ObstructionIntestine, SmallMaleMiddle AgedObserver VariationRadiologistsRadiometryReproducibility of ResultsRetrospective StudiesTomography, X-Ray Computedcomputer-aided image analysisCT enterographyintestinal fibrosisMR enterographyradiomicssegmentation

Identifiers

PMID31504540
PMCPMC7150581
OpenAlexW2970606297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.