Observational studyEuropean heart journal2020
Long-term outcomes of chronic coronary syndrome worldwide: insights from the international CLARIFY registry.
Observational study in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Chinese patent medicine tongxinluo capsule as a supplement to treat chronic coronary syndromes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2024Pooled it
- The Efficacy and Safety of Proton Pump Inhibitors Combining Dual Antiplatelet Therapy in Patients with Coronary Intervention: A Systematic Review, Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials.Reviews in cardiovascular medicine · 2023Pooled it
- Efficacy of Telemedical Interventional Management in Patients with Coronary Heart Disease Undergoing Percutaneous Coronary Intervention: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Efficacy and Safety of Suxiao Jiuxin Pills in the Treatment of Chronic Coronary Syndrome with Intolerance to Adverse Effects of Long-acting Nitrates: A Multicenter, Randomized, Double-blind, Placebo-controlled Study.BMC complementary medicine and therapies · 2024Trial
- Cardiologists' Diagnostic and Therapeutic Approaches in the Outpatient Management of Patients with Chronic Coronary Syndrome in Turkey: An Observational-Registration Study.Journal of cardiovascular development and disease · 2026Article
- A Patient and Physician Perspective of Chronic Coronary Syndrome and Persistent Stable Angina in Brazil.Cardiology and therapy · 2026Review
- From anatomy to vulnerability: A comprehensive appraisal of coronary physiology and plaque characterization.American heart journal plus : cardiology research and practice · 2026Review
- Korean Society of Interventional Cardiology Expert Consensus for the Management of Chronic Coronary Syndrome: Part 2.Korean circulation journal · 2026Review
- Five-Year Mortality among Survivors of Coronary Artery Bypass Graft Surgery: A Retrospective Study from a Tertiary Center.Arquivos brasileiros de cardiologia · 2026Article
- Sex differences in monitoring and achievement of blood pressure and LDL-cholesterol targets in chronic coronary syndrome.Upsala journal of medical sciences · 2026Article
- Association between neutrophil extracellular traps, the Von Willebrand factor axis, and clinical outcome in stable coronary artery disease.Frontiers in cardiovascular medicine · 2026Article
- Hospitalizations for Major Cardiovascular Events in Patients Aged 75 Years or Older with Chronic Coronary Syndrome for the Whole Life Span.Journal of clinical medicine · 2025Article
- Left ventricular systolic function after percutaneous coronary intervention: patterns of change and prognosis according to clinical presentation of coronary artery disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Temporal Trend Analysis of Atrial Fibrillation/Flutter Disease Burden in High-Income Countries Between 1990 and 2021.Reviews in cardiovascular medicine · 2025Article
- Enhanced risk stratification in chronic coronary syndrome using the left atrioventricular coupling index.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Efficacy and Safety of Low-Dose Rivaroxaban in High-Ischemic-Risk Patients with Chronic Coronary Syndrome: Rationale and Design of the DUTCH CCS Registry.Journal of clinical medicine · 2025Article
- Effectiveness and Tolerability of Trimetazidine 80 mg Once Daily in Patients with Chronic Coronary Syndrome in Brazil: The V-GOOD Observational Study.Cardiology and therapy · 2025Article
- Diagnosing and treating stable angina: a contemporary approach for practicing physicians.Future cardiology · 2025Review
- The burden of atrial fibrillation/atrial flutter in Europe from 1990 to 2021, with a forecast of incidence through 2044.Frontiers in cardiovascular medicine · 2025Article
- Imaging approaches in risk stratification of patients with coronary artery disease: a narrative review.Archives of medical science : AMS · 2025Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsOver the last decades, the profile of chronic coronary syndrome has changed substantially. We aimed to determine characteristics and management of patients with chronic coronary syndrome in the contemporary era, as well as outcomes and their determinants. METHODS AND
resultsData from 32 703 patients (45 countries) with chronic coronary syndrome enrolled in the prospective observational CLARIFY registry (November 2009 to June 2010) with a 5-year follow-up, were analysed. The primary outcome [cardiovascular death or non-fatal myocardial infarction (MI)] 5-year rate was 8.0% [95% confidence interval (CI) 7.7-8.3] overall [male 8.1% (7.8-8.5); female 7.6% (7.0-8.3)]. A cox proportional hazards model showed that the main independent predictors of the primary outcome were prior hospitalization for heart failure, current smoking, atrial fibrillation, living in Central/South America, prior MI, prior stroke, diabetes, current angina, and peripheral artery disease. There was an interaction between angina and prior MI (P = 0.0016); among patients with prior MI, angina was associated with a higher primary event rate [11.8% (95% CI 10.9-12.9) vs. 8.2% (95% CI 7.8-8.7) in patients with no angina, P < 0.001], whereas among patients without prior MI, event rates were similar for patients with [6.3% (95% CI 5.4-7.3)] or without angina [6.4% (95% CI 5.9-7.0)], P > 0.99. Prescription rates of evidence-based secondary prevention therapies were high.
conclusionThis description of the spectrum of chronic coronary syndrome patients shows that, despite high rates of prescription of evidence-based therapies, patients with both angina and prior MI are an easily identifiable high-risk group who may deserve intensive treatment. CLINICAL REGISTRY: ISRCTN43070564.
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