ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Trends in Hepatitis B Infection and Immunity Among Women of Childbearing Age in the United States.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Impact of Removing the Universal Hepatitis B Birth-Dose Vaccination in the US.JAMA pediatrics · 2026Article
- Hepatitis B Virus Treatment Gaps in the US.JAMA network open · 2025Article
- Exploring blood lipids-immunity associations following HBV vaccination: evidence from a large cross-sectional study.Frontiers in cellular and infection microbiology · 2024Article
- Screening and Testing for Hepatitis B Virus Infection: CDC Recommendations - United States, 2023.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2023Article
- Age-specific seroprotection after Hepatitis B virus vaccination among Korean American pediatric population in Queens, New York.Human vaccines & immunotherapeutics · 2022Article
- Hepatitis C is associated with more adverse pregnancy outcomes than hepatitis B: A 7-year national inpatient sample study.Hepatology communications · 2022Article
- Chronic Hepatitis B and HIV Coinfection: A Continuing Challenge in the Era of Antiretroviral Therapy.Current hepatology reports · 2020Article
- Variations in Hepatitis B Vaccine Series Completion by Setting Among Adults at Risk in West Virginia.American journal of preventive medicine · 2020Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe current opioid injection drug use epidemic has been associated with an increase in hepatitis C virus infections among women of childbearing age in the United States, but changes in hepatitis B virus (HBV) infections have not been studied.
methodsA retrospective analysis of HBV statuses among women of childbearing age nationally and by state was conducted, utilizing the Quest Diagnostics database. Rates of HBV in women born before and after the implementation of universal HBV vaccination recommendations were determined.
resultsWe identified 8 871 965 women tested for HBV from 2011-2017. Nationally, the annual rate of acute HBV infections was stable, but rates increased in Kentucky, Alabama, and Indiana (P < .03). The national prevalence of new, chronic HBV diagnoses decreased significantly, from 0.83% in 2011 to 0.19% in 2017 (P < .0001), but increased in Mississippi, Kentucky, and West Virginia (P ≤ .05). A declining prevalence of HBV seroprotection was evident over time, especially within the birth-dose cohort (which dropped from 48.5% to 38.5%; P < .0001).
conclusionsNational rates of newly diagnosed acute and chronic HBV infections declined or were stable overall, but increased significantly in specific Appalachian states. The HBV vaccine is effective in decreasing infections, but seroprotection wanes over time. These trends in new infections may be related to increased injection drug use and highlight potential gaps in HBV vaccine protection.
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