ArticleCerebral cortex (New York, N.Y. : 1991)2020
Direct Electrical Stimulation of Premotor Areas: Different Effects on Hand Muscle Activity during Object Manipulation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06381726 (Personalized Rendering of Motor System Functional Plasticity Potential to Improve Glioma Resection and Quality of Life), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Personalized Rendering of Motor System Functional Plasticity Potential to Improve Glioma Resection and Quality of Life
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- A probabilistic map of motor and cognitive functions: a meta-analysis of 4325 stimulation sites.Brain structure & function · 2025Pooled it
- An update on tests used for intraoperative monitoring of cognition during awake craniotomy.Acta neurochirurgica · 2024Pooled it
- Object-oriented hand dexterity and grasping abilities, from the animal quarters to the neurosurgical OR: a systematic review of the underlying neural correlates in non-human, human primate and recent findings in awake brain surgery.Frontiers in integrative neuroscience · 2024Pooled it
- Recruitment of the central nervous system in different hand tasks in patients with hand dysfunction after stroke based on functional near-infrared spectroscopy: an exploratory study.Journal of rehabilitation medicine · 2026Observational
- Convergent causal mapping unravels distinct frontal networks for visuospatial selective attention.Nature communications · 2025Article
- The neural bases of the reach-grasp movement in humans: Quantitative evidence from brain lesions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- From non-human to human primates: a translational approach to enhancing resection, safety, and indications in glioma surgery while preserving sensorimotor abilities.Frontiers in integrative neuroscience · 2025Review
- The parietal architecture binding cognition to sensorimotor integration: a multimodal causal study.Brain : a journal of neurology · 2024Article
- Connectivity defines the distinctive anatomy and function of the hand-knob area.Brain communications · 2024Article
- Brain activity associated with quadriceps strength deficits after anterior cruciate ligament reconstruction.Scientific reports · 2023Article
- Synchronization of kinetic and kinematic hand tasks with electrocorticography and cortical stimulation during awake craniotomies.PloS one · 2023Article
- Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities.Frontiers in human neuroscience · 2023Review
- Stimulation of frontal pathways disrupts hand muscle control during object manipulation.Brain : a journal of neurology · 2022Article
- Synergistic Immediate Cortical Activation on Mirror Visual Feedback Combined With a Soft Robotic Bilateral Hand Rehabilitation System: A Functional Near Infrared Spectroscopy Study.Frontiers in neuroscience · 2022Article
- Article
- Distinct Functional and Structural Connectivity of the Human Hand-Knob Supported by Intraoperative Findings.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Clinical Pearls and Methods for Intraoperative Motor Mapping.Neurosurgery · 2021Review
- Reproducing macaque lateral grasping and oculomotor networks using resting state functional connectivity and diffusion tractography.Brain structure & function · 2020Article
- Direct electrical stimulation of the premotor cortex shuts down awareness of voluntary actions.Nature communications · 2020Article
- Navigated transcranial magnetic stimulation of the supplementary motor cortex disrupts fine motor skills in healthy adults.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dorsal and ventral premotor (dPM and vPM) areas are crucial in control of hand muscles during object manipulation, although their respective role in humans is still debated. In patients undergoing awake surgery for brain tumors, we studied the effect of direct electrical stimulation (DES) of the premotor cortex on the execution of a hand manipulation task (HMt). A quantitative analysis of the activity of extrinsic and intrinsic hand muscles recorded during and in absence of DES was performed. Results showed that DES applied to premotor areas significantly impaired HMt execution, affecting task-related muscle activity with specific features related to the stimulated area. Stimulation of dorsal vPM induced both a complete task arrest and clumsy task execution, characterized by general muscle suppression. Stimulation of ventrocaudal dPM evoked a complete task arrest mainly due to a dysfunctional recruitment of hand muscles engaged in task execution. These results suggest that vPM and dPM contribute differently to the control of hand muscles during object manipulation. Stimulation of both areas showed a significant impact on motor output, although the different effects suggest a stronger relationship of dPM with the corticomotoneuronal circuit promoting muscle recruitment and a role for vPM in supporting sensorimotor integration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.