ArticleBrain : a journal of neurology2019
Handedness, language areas and neuropsychiatric diseases: insights from brain imaging and genetics.
Article in Brain : a journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 6 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- DNA methylation in peripheral tissues and left-handedness.Scientific reports · 2022Pooled it
- Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group.Brain imaging and behavior · 2021Pooled it
- Genome-wide association study identifies 48 common genetic variants associated with handedness.Nature human behaviour · 2021Pooled it
- [Research progress on genetic effects of the asymmetry of human brain structure revealed by magnetic resonance imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Pooled it
- Four meta-analyses across 164 studies on atypical footedness prevalence and its relation to handedness.Scientific reports · 2020Pooled it
- Language and reading impairments are associated with increased prevalence of non-right-handedness.Child developmentPooled it
- Genetic frontotemporal degeneration across the lifespan? A critical appraisal of the neurodevelopmental hypothesis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Lifespan Trajectories of Asymmetry in White Matter Tracts.Human brain mapping · 2026Article
- Structural and functional brain asymmetry in relation to heterogeneous causes of situs inversus totalis.Brain structure & function · 2026Article
- Transcriptomics and functional genomics implicate WNT3 in hemispheric lateralization of speech production.iScience · 2026Article
- Aberrant topology of the default mode network is associated with phosphatidylcholine and triglyceride levels in major depressive disorder.World journal of psychiatry · 2026Article
- Non-right-handedness and psychiatric disorders: A synthesis of epidemiological, genetic, and neurobiological evidence.World journal of psychiatry · 2026Review
- Study protocol for the Champaign-Urbana population study.Frontiers in neuroimaging · 2026Article
- Psychometric Properties of the UCSF Fein MAC Educational & Developmental History Questionnaire:: A Novel Screening Tool for Capturing Early Life Learning Profiles Across Healthy Aging and Dementia Populations.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Demographic and Clinical Characteristics in Different Motor Subtypes of Parkinson's Disease: How Well Do the Findings Fit Within the Framework of Existing Hypotheses?Neurology international · 2025Article
- Brain handedness associations depend on how and when handedness is measured.Scientific reports · 2025Article
- Explore autophagy-related lncRNA-miRNA-mRNA ceRNA networks for diagnosis of early-onset schizophrenia through transcriptome analysis.Frontiers in psychiatry · 2025Article
- Perinatal adversities as a common factor underlying the association between atypical laterality and neurodevelopmental disorders: A developmental perspective.Psychophysiology · 2024Review
- Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness.Communications biology · 2024Article
9 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Ninety per cent of the human population has been right-handed since the Paleolithic, yet the brain signature and genetic basis of handedness remain poorly characterized. Here, we correlated brain imaging phenotypes from ∼9000 UK Biobank participants with handedness, and with loci found significantly associated with handedness after we performed genome-wide association studies (GWAS) in ∼400 000 of these participants. Our imaging-handedness analysis revealed an increase in functional connectivity between left and right language networks in left-handers. GWAS of handedness uncovered four significant loci (rs199512, rs45608532, rs13017199, and rs3094128), three of which are in-or expression quantitative trait loci of-genes encoding proteins involved in brain development and patterning. These included microtubule-related MAP2 and MAPT, as well as WNT3 and MICB, all implicated in the pathogenesis of diseases such as Parkinson's, Alzheimer's and schizophrenia. In particular, with rs199512, we identified a common genetic influence on handedness, psychiatric phenotypes, Parkinson's disease, and the integrity of white matter tracts connecting the same language-related regions identified in the handedness-imaging analysis. This study has identified in the general population genome-wide significant loci for human handedness in, and expression quantitative trait loci of, genes associated with brain development, microtubules and patterning. We suggest that these genetic variants contribute to neurodevelopmental lateralization of brain organization, which in turn influences both the handedness phenotype and the predisposition to develop certain neurological and psychiatric diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.